Wednesday - Dirty D - receptors and the MHC

Question 1

CD28

on what cells
binds what
makes what

Answer 1

On T cells
Binds CD 80, 86 on APCs
Produces IL-6

Question 2

Th1 CD4 T cell

polarized by:
effector cytokines produced:
role:

Answer 2

polarized by: IL-12, 18, INF-gamma (and T-BET…?)

effector cytokines produced: INF-gamma (most important is a proinflammatory and chemotactic agent for blood monocytes, which become M1 angry macrophages) and TNF

role: cell mediated immunity, INF-gamma makes angry macrophages, inflammation

Question 3

Th17 CD4 T cell

polarized by:
effector cytokines produced:
role:

Answer 3

polarized by: IL-1, 6, 23, TGF-beta

effector cytokines produced: IL-17, IL-22

role: IL- 17, 22 activate multiple inflammatory cells

Question 4

Th2 CD4 T cell

polarized by:
effector cytokines produced:
role:

Answer 4

polarized by: IL-4

effector cytokines produced: IL-4,5,13

role: IL-4,13 make M2 macrophages. 4,5 attract eosinophils, allergic and antihelminth response.

Question 5

Follicular helper CD4 T cells

polarized by:
effector cytokines produced:
role:

Answer 5

polarized by: IL-6, 21

effector cytokines produced: IL-4, 21

role: helps b cells differentiate in germinal centers

Question 6

Treg CD4 t cell

polarized by:
effector cytokines produced:

Answer 6

polarized by: IL-1, TGF-beta

effector cytokines produced: IL-10, TGF-beta

role: suppresses Th1,2,17, and fh via IL-10, TGF-beta

Question 7

IPEX

Answer 7

lack Treg cells/activity

Question 8

another name for the b cell receptor

Answer 8

CD79 and CD79b

Question 9

LFA-1

on what
binds to what

Answer 9

on T cells. Binds ICAM on APCs

Question 10

CD2

on what
binds to what

Answer 10

on T cells

binids LFA-3 on APCs

Question 11

Which chain on the t cell receptor is like the light chain in that it only has V and J?

which is like heavy?

Answer 11

alpha is like light

beta is like heavy

Question 12

Which MHC has the beta2-microglobulin?

Answer 12

MHC I

Question 13

uhhh

Answer 13

HLA alphas can complex with any beta 2 microglobulin?

Question 14

MHC-___

means MHC class II molecules

Answer 14

MHC - DR, DP, DQ

Question 15

Disease associated with polymorphisms of:

HLA-B27

Answer 15

90x more likely to develope ankylosing spondylitis (destruction of the vertebral cartilage)

Question 16

Disease associated with polymorphisms of:

HLA-DR2

Answer 16

130x more likely to develop narcolepsy

Question 17

Disease associated with polymorphisms of:

HLA-A3/B14

Answer 17

90x more likely to develop hemochromatosis (too much iron)

Question 18

Disease associated with polymorphisms of:

HLA-DQ2/GQ8

Answer 18

linked to celiac

Question 19

Disease associated with polymorphisms of:

HLA-DR3

Answer 19

DM type I, Grave’s disease

Question 20

Disease associated with polymorphisms of:

HLA-DR4

Answer 20

rheumatoid arthritis and DM type I

Question 21

Disease associated with polymorphisms of:

HLA-B53

Answer 21

Trick question?

PROTECTION against malaria

Question 22

T cell negative selection

Answer 22

T cells that recognise self MHC are terminated

Question 23

Difference in allotype dominance between TCRs and BCRs

Answer 23

TCRs are “codominant” in that one beta from mom can be with one alpha from dad, or one beta from mom can be with one alpha from mom

BCRs are either just you moms or your dads