Wednesday, 8-24-Multiple Sclerosis-Hon Flashcards
What is the most common type of MS?
Relapsing remitting (45-50%)
When are most MS patients diagnosed with the disease?
In their 20s and 30s
MS is generally characterized by:
Periods of exacerbation and remission
Which gender is often more affected with MS? Which gender generally has a more favorable course?
Affects women more than men (1.5:1)
Women generally have a more favorable course
At what age or time frame is the onset of MS more favorable prognostically?
In general, earlier onset is a more favorable prognostic feature
In an MRI of the had and neck, MS pts typically have ovoid lesions of high signal on T2WI in the ___
Periventricular white matter and in the SC. Acute lesions may enhance
The presence of ___ in an LP CSF is a typical finding in MS:
Oligoclonal bands and/or increased IgG
MS is diagnosed by ___
Multiple lesions over space and time
Avonex, rebif (interferon beta-1a), Betaseron (interferon beta-1b), and copaxone (glatirimer acetate) are drugs used for:
Maintenance in MS –> To decrease the FREQUENCY and SEVERITY OF EXACERBATIONS and slow the progression of the disease
These are all injectables
Avonex, rebif (Interferon Beta-1a), Betaseron (interferon beta-1b), and Copaxone (glatirimer acetate) are used in pts with ___ MS
Relapsing remitting
Betaseron is the only one approved for chronic progressive MS
What med(s) are used to treat an acute exacerbation in MS?
High dose corticosteroids (Solumedrol-1 gram IV daily for 5 days followed by Prednisone taper)
This generally reduces the length of the exacerbation, but is not thought to change the overall outcome of it
Baclofen is first line therapy for treating ___ in MS
Spasticity
Propanolol, primidone, and clonazepam are used to treat ___ in MS
Intention tremor
Oxybutynin, Detrol LA are used to treat ___ in MS
Urinary urgency (spastic bladder)
Bethanechol is used to treat ___ in MS
Urinary retention/hesitancy
