Wed 2 NSAID

Question 1

two main enzymes that work on arachadonic acid and what they can make from it

Answer 1

lipoxygenase: leukotrienes

Cyclooxygenase: prostaglandins, thromboxane, prostacyclin.

Question 2

Prostaglandins

Answer 2

vasodilation,
gastic cytoprotection,
nociceptor sensitization!

Question 3

Thromboxanes

Answer 3

platelet aggregation!, inflammation

Question 4

Prostacyclin

Answer 4

vasodilation
gastric cytoprotection
inhibits platelet aggregation!

Question 5

COX 1 vs COX 2

Answer 5

1: NORMAL PHYSIOLOGY gastric cytoprotection, vasodilation, platelet aggregation
2: INDUCABLE acute inflammation

Question 6

prostaglandin involved in fever

Answer 6

PGE2

Question 7

Adverse effects of high dose aspirin

Answer 7

Respiratory alkalosis - hyperventilation increases blood pH

GI bleed

if dose is at toxin levels, aspirin can uncouple oxidative phosphorylation (primarily in skeletal muscle) lactic acid accumulates in serum, decreases blood pH.

dehydration, agitation, etc.

Question 8

Tx of aspirin overdose

Answer 8

induce vomitin, activated charcoal, give sodium bicarb if acidotic

can need transfusion, dialysis

Question 9

Cause of aspirin hypersensitivity

treat with

Answer 9

build up of A.A. causes influx into leukotriene pathway, bronchial constriciton

Tx: epi

Question 10

Reye’s syndrome

Answer 10

aspirin use in presence of viral infection

Question 11

naproxen general

Answer 11

similar to ibuprofen, longer acting