Weakness Flashcards

1
Q

What are the things to consider when assessing weakness

A

Onsent- rapid, slow onset
How has it progressed on how long did it last
What is the pattenr of the weakness
Upper and lower motor neurone pattern or neither
Any unusual pathogonomic features

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2
Q

If it was a sudden onsent what could this suggest

A

Vascular problem e.g stroke

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3
Q

What is episodic

A

Recurrent episodes and returning to normal between times

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4
Q

Examples of a disease that can cause episodic weakness

A

Myasthenia gravis

Relapsin remitting multiple sclerosis

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5
Q

What are the types of continous/progressive illness

A
Acutely progressive (hours)
Intermediately progressive (days to weeks) 
Slowly progressive or chronic (weeks to years)
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6
Q

What can occur as acutely progressive

A

Myasthenic crisis

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7
Q

What can occur intermediately progressive

A

Tranverse myelitis
Gullian barre syndrome
Cervical myelopathy/cauda equina syndrome

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8
Q

What can occur slowly progessive or chronic

A

Primary progressive or secondary progressive multiple sclerosis
Cervical myelopathy/ cauda equina syndrome
Motor neuron disease
Inherited nerve/muscle disorder
Myopathies

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9
Q

What has a relapsing remitting trajectory

A

Mutliple sclerosis

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10
Q

In an upper motor neurone weaknnes which muscle group is stronger in the arms

A

Flexors stronger than extensors

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11
Q

In a lower motor neurone disease what muscle groups are stronger in the lefs

A

Extensors stronger than flexors

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12
Q

What are the patterns of weakness in a umn lesion

A

Hemispheric lesion
Brainstem lesion
Spinal cord lesion

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13
Q

When can a hemispheric lesion and brainstem lesion occur

A

Sudden onset- vascular e.g stroke, infarct or haemorrhage

Subacute or progressive e.g tumour or abscess

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14
Q

What type of pattern can occur in a spinal cord lesion

A

Sudden- Spinal cord stroke
Subacute- tranverse myelitis (cord inflammation)
Gradullay progressive: spinal tumour, spinal vascular process

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15
Q

What are the patterns of weakness in lower motor neurone disease

A

Polyneuropathy

Monomelic

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16
Q

What is polyneuropathy

A

Hands and feet are affected

17
Q

What does polyneruopathy suggest

A

Peripheral neuropathy

18
Q

If peripheral neuropathy is subacute/intermediate acute over hours to days what can it be

A

Gullian barre syndrome

19
Q

If peripheral neuropathy is chronic what are the causes

A

Dibatetic/alcohol

B12, folate or hypothyroidism

20
Q

What is a monomelic pattern

A

Focal which is isolated to one limb

21
Q

What are the causes of monomelic pattern

A

Stroke (UMN)
Multilevel cervical radiculopathy (lmn)
Brachical plexus (lmn)
Multifocal motor neuropathy (lmn)

22
Q

What is myasthenia gravis

A

Due to dysfunction of neuromuscular junction
No sensory loss
There is respiratory and fascial weakness

23
Q

What signs does amyotrophic lateral sclerosis show

A

Mixed umn and lmn signs