Weak D- Deficiency

Question 1

About 1% of D-positive individuals type as

Answer 1

Weak D

Question 2

former name of weak D antigen

Answer 2

Du

Question 3

Is weak D a new antigen? Yes or No

Answer 3

No, not a new antigen because people did not produce anti-Du but anti-D

Question 4

Red Cells fails to react or reacts weakly to agglutination tests (but will react in IAT)

Answer 4

Weak D (Quantitative)

Question 5

Cells carrying a weak D antigen require the use of what test to demonstrate its presence?

Answer 5

Indirect antiglobulin test

Question 7

Rh antigen on RBC is normal, but the steric arrangement of the C antigen in relationship to the D antigen appears to interfere with the expression of D antigen

Answer 7

C-trans RHD

Question 8

From the inheritance of RHD genes that code for weakened expression of the D antige

Answer 8

Weak D (Quantitative

Question 9

The changes does not alter or remove any D epitopes therefore production of anti-Rh is not possible

Answer 9

Weak D (Quantitative)

Question 10

Weak D expression that is common in black

Answer 10

Weak D (quanti)

Question 11

antibody production in this type of expression is less likely

Answer 11

Weak D

Question 12

People with this blood type can receive D positive RBCs

Answer 12

C trans in RHD

Question 13

One or more D epitopes within the entire D protein is missing or altered

Answer 13

Partial D

Question 14

individuals who were type D-positive express this antigen but produced an anti-D that reacted with all D-positive samples except their own

Answer 14

Partial D

Question 15

In partial D, If an individual lacks one or more pieces(epitopes), of the total D antigen, what can be made to the missing epitopes if exposed to RBCs that possess the complete D antigen.

Answer 15

alloantibody

Question 16

classified the antigens

Answer 16

Patricia Tippett and Ruth Sanger

Question 17

Tested anti-D sera from D-positive people with RBCs from other D-positive people who also made anti-D

Answer 17

Patricia Tippett and Ruth Sanger

Question 18

Number of categories Patricia Tippett and Ruth Sanger assigned for antigen

Answer 18

7

Question 19

Antibody that Patricia Tippett and Ruth Sanger used to classify antigen

Answer 19

monoclonal(MAb-D)antibodies

Question 20

Resulting protein contains a portion of RhD and RhCE in various combinations

Answer 20

Partial D

Question 21

Anti-D made by Partial D person can cause

Answer 21

HDN or HTR

Question 22

UseRh(-)blood for transfusion

Answer 22

Partial D

Question 23

Rh type used for partial D blood transfusion

Answer 23

Rh negative

Question 24

D epitopes is found on the surface of this protein

Answer 24

RhCE protein

Question 25

results from a hybrid gene“RHCE-RHD-RHCE”

Answer 25

R0Har – “DHAR”

Question 26

Only a small portion of RHD is inserted into the RHCE gene

Answer 26

RoHar

Question 27

If RoHar is paired with a normal RHD gene, the person will type

Answer 27

Rh positive

Question 28

found in individuals of African descent

Answer 28

Crawford antigen (ceCF)(Rh43)

Question 29

Due to a specific amino acid change in the Rhce gene

Answer 29

Crawford antigen

Question 30

Results for an RhD epitope on the Rhce protein

Answer 30

Crawford

Question 31

Phenotype in individuals whose RBCs possess an extremely low number of D antigen sites that most reagent anti-D are unable to detect

Answer 31

Del

Question 32

Mutant, RHD gene that alters expression of the RhD protein

Answer 32

Del

Question 33

In Del, splice site mutation happens in

Answer 33

exon 9 of RHD in Asians (or M295I mutation in whites)

Question 34

high incidence in Hong Kong Chinese and Japanese people

Answer 34

Del

Question 35

May be typed as D negative and can be found only when they stimulate production of anti-D in D negative individuals

Answer 35

Del

Question 36

May require adsorbing and elution techniques

Answer 36

Del

Question 37

process of gathering/pulling molecules onto the surface.

Answer 37

Adsorbing

Question 38

process of removing molecules from a source or cellular

Answer 38

Elution

Question 39

Have Rh negative with deletion of the RHD gene

Answer 39

European

Question 40

Genes that are only available in Rh negative European

Answer 40

2 RHCE genes

Question 41

Rh negative gene for Africans

Answer 41

RHD pseudogene (RHD ѱ)

Question 42

Rh negative allele in Africans have 37 base pair insertion at the

Answer 42

intron3/exon4

Question 43

Person with this gene does not produce RhD proteins

Answer 43

RHD pseudogene

Question 44

RHD pseudogene in Africans does not produce this protein

Answer 44

RHD

Question 45

Reagent use for indirect agglutination test

Answer 45

Coomb's reagent

Question 46

Weak D positive reaction in indirect agglutination test

Answer 46

Agglutination

Question 47

fail to express any Rh antigens on the RBC surface

Answer 47

Rhnull

Question 48

Rhnull syndrome sign

Answer 48

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