Rh group (History to terminology)

Question 1

ISBT number 004

Answer 1

Rh blood group

Question 2

Convert the following genotypes from Wiener nomenclature to Fisher-Race and Rosenfield nomenclatures, and list the antigens present in each haplotype.

a. R1r
b. R2R0
c. RzR1
d. rr

Answer 2

R1r
DCe/dce
Rh:1, 2, -3, 4, 5

R2R0
DcE/Dce
Rh:1, -2, 3, 4, 5

RzR1
DCE/DCe
Rh:1,2,3, -4,5

ryr
dCE/dce
RH: -1,2,3,4,5

Question 3

What theory in 1940s, said that each person inherits a set of Rh genes from each parent (one D or d, one C or c, one E or e), because Rh genes are thought to be CODOMINANT

Answer 3

Fisher-Race

Question 4

Rh-hr terminology: presence of CE (with D)

Answer 4

Z

Question 5

When was Rh phenotype was reported in order of DCE

Answer 5

1946

Question 6

How are Rh antigens inherited?

Answer 6

Codominant alleles

Question 7

Introduced a new terminologies for Rh group in 1962

Answer 7

Richard Rosenfield and Co workers

Question 8

“C” gene frequency for RH antigens in Caucasians

Answer 8

70%

Question 9

Rh was named from

Answer 9

Rhesus Monkey

Question 10

antigen is most potent, found in 85% of the white population and is always significant for transfusion purposes

Answer 10

D antigen

Question 11

This case is where Dr. Levine found that over 90% is rh neg mother and rh positive father.

Answer 11

Erythroblastosis fetalis

Question 12

“e” gene frequency for RH antigens in Caucasians

Answer 12

98%

Question 13

Interpret this using “Alphanumeric Terminology

1,2,-3,5

Answer 13

Presence of D, C, e but absence of c

Question 14

Created to more accurately represent the serological daya and to be more compatible with computer use

Answer 14

Alphanumeric Terminology

Question 15

This terminology may be considered the phenotypic expression of the haplotype

Answer 15

Rh-hr terminology

Question 16

It represents the presence of a single haplotype expressing three different factors

Answer 16

agglutinogen

Question 17

Termsed for Anti-rhesus produced by animals

Answer 17

Anti-LW

Question 18

Most commonly use terminology for Rh grouping

Answer 18

Fisher-Race or DCE term

Question 19

Reported an antibody made by guinea pigs and rabbits when transfused with Rhesus monkey

Answer 19

Dr. Landsteiner and Dr. Alexander S. Wiener

Question 20

The complement of genes inherited from either parent

Answer 20

Haplotype

Question 21

Indicates that an individual’s rbc possess one particular Rh antigen (D antigen)

Answer 21

Rh positive

Question 22

Rh-hr terminology: indicates absence of antigen

Answer 22

r

Question 23

Under ISBT: what number was assigned to Rh blood group

Answer 23

004

Question 24

represents the absence of D antigen in fisher race theory

Answer 24

d (small d)

Question 25

Weiner symbol

Answer 25

Rh-hr

Question 26

who described an HTR on an obstetrical patient after delivering a stillborn infant in 1939

Answer 26

Dr. Philip Levine and Rufus Stetson

Question 27

There are reports about Hemolytic transfusion reactions & HDN in this year

Answer 27

1930s

Question 28

When was HDN first described?

Answer 28

1609

Question 29

presence of Ce without D

Answer 29

'

Question 30

Termed the fisher-race

Answer 30

Ronald Aylmer Fisher and Dr. Robert Russel Race

Question 31

No genetic basis, no involve theory of Rh inheritance

Answer 31

“Alphanumeric Terminology

Question 32

D gene frequency for RH antigens in Caucasians

Answer 32

85%

Question 33

This system has no genetic basis, nor was it proposed based on a theory of Rh inheritance, but it simply demonstrates the presence or absence of the antigen on the RBC.

Answer 33

Rosenfield (alphanumeric)

Question 34

Indicates presence of D for Rh-hr terminology

Answer 34

"R"

Question 35

Who termed the Rh-hr terminology

Answer 35

Dr. Alexander Weiner

Question 36

Number of digits per antigen under ISBT

Answer 36

6

Question 37

For ISBT: First 3 digits represents the ____ and the remaining 3 represent the ___

Answer 37

1. system 2. antigenic specificity

Question 38

C and c antigens for Fisher race recognizes what antigen

Answer 38

Anthetical

Question 39

establishes a uniform nomenclature that is both eye and machine readable and is in keeping with the genetic basis of blood groups

Answer 39

International Society of Blood Transfusion Committee

Question 40

What causes the erythroblastosis fetalis in the findinga of Dr. levine in 1941

Answer 40

Maternal antibody

Question 41

Who believed that there was one gene responsible for defining Rh that produced an agglutinogen

Answer 41

Weiner

Question 42

Rh antibodies reacts best at

Answer 42

37C

Question 43

Proposed a system that assigns a number to each antigen of the Rh system in order of its discovery or recognized relationship to the Rh system

Answer 43

Richard Rosenfield and Coworkers

Question 44

Second most important blood system in terms of transfusion

Answer 44

Rh group

Question 45

This terminology was followed for written communication

Answer 45

Fisher-Race

Question 46

Presence of cE without D

Answer 46

"

Question 47

Hemolytic disease of the fetus and newborn also called as

Answer 47

Erythroblastosis fetalis

Question 48

Rh-hr terminology: for presence of ce

Answer 48

0

Question 49

Presence of CE without D

Answer 49

y