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BB Quiz1 Semi > Quiz 1 Semis > Flashcards

Quiz 1 Semis Flashcards

1
Q

This antigenic integral membrane glycoprotein crosses the RBC membrane multiple times

A

Aquaporin 1 -

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2
Q

Acquired hematopoietic stem cell disorder that results from the absence or deficiency in expression of GPIlinked proteins

A

Paroxysmal Nocturnal
Hemoglobinuria

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3
Q

Yt weak immunogen antibody

A

Anti-Ytᵇ

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4
Q

Both Doª and Doᵇ genes are codominant alleles that differs in ____ nucleotide
positions

A

three

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5
Q

3 phenotypes of Cartwright

A

Yt(a+b-), Yt(a+b+), Yt(a-b+)

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6
Q

Observed from multiparous women ; common in children&patients w/ Bacterial infection

A

Anti-M

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7
Q

antigens are not intrinsic to the RBC membrane

A

Chido-Rodgers

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8
Q

Rare in most populations but is more polymorphic in people of Mongoloid ancestry

A

. Diª

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9
Q

antibodies Can be significant in transfusion

A

Gerbich

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10
Q

Lutheran system is composed of how many antigens

A

20

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11
Q

Neutralization with pooled plasma is used to identify this antibodies

A

Chido-Rodgers

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12
Q

high prevalence antigen in all populations

A

Yta

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13
Q

Who discovered antigen S and s

A

Discovered in 1947 by Walsh and Carmel Montgomery

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14
Q

Which antigens are formed on Glycoprotein C and D, similar to MNS? These contribute to what 2 aspects of the RBC?

A

Gerbich antigens (Ge)
Membrane integrity and negative charge

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15
Q

Causes immediate HTR

A

Indian Antibodies

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16
Q

IgM and are naturally occurring saline agglutinins

A

Anti-Luª

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17
Q

Found on RBCs of all individuals except about 1% of African Americans

A

U (MNS5)

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18
Q

Anti-N lectins

A

Vicia graminea
Bauhinia variegata
Bauhinia purpura

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19
Q

G from XG blood group was named after

A

Grand Rapids where the patient was treated

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20
Q

Named after the first antibody maker from a Venezuelan family during an investigation of HDFN

A

Diego

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21
Q

Reacts at room temperature and some can bind complement; Causes delayed HTRs

A

Anti-Luª

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22
Q

Have a prevalence of more than 90% in most populations

A

Knops antigen

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23
Q

Lu antigens are important for

A
  1. adhesion properties
  2. mediation of intracellular signaling
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24
Q

gene location of Indian Blood Group

A

Chromosome 11p13

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25
Q

The Scianna antigens are resistant to ___ and ___, and are weakened by ______

A

ficin and papain
Dithiothreitol

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26
Q

Single nucleotide mutation in Yt gene causes an amino acid change at position

A

353

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27
Q

Discovered U antigen

A

Weiner

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28
Q

gene(CR1) responsible for the group is at chromosome1q32

A

Knops

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29
Q

Not present on other blood cells but are detected in other tissues such as the brain, lungs, pancreas, placenta, skeletal muscle, and hepatocytes

A

Lutheran Antigens

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30
Q

Lutheran antigens are located on

A

type 1 transmembrane protein

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31
Q

The antigens are on the fourth component of C4 and are just adsorbed to the RBCs from the plasma

A

Chido-Rodgers

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32
Q

has threonine at position 117

A

Joseph (Jo^a)

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33
Q

GPA and GPB are also expressed in (2 pts)

A

renal endothelium an epithelium

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34
Q

Reacts with DAT;

A

Dombrock antibodies

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35
Q

only group associated with a complement protein

A

Chido-Rodgers

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36
Q

The gene that codes for the antigen is the aquaporin 1 (AQP1)

A

Colton

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37
Q

What antibody can be found in multiply transfused patients, like those with thalassemia or sickle cell?

A

Anti-Kna (Knops)

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38
Q

Detected on fetal RBCs as early as 10-12 weeks of gestation but are poorly developed at birth

A

Lutheran Antigens

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39
Q

an IgG antibody reactive at the
antiglobulin phase; it is usually produced in response to
foreign RBC exposure during pregnancy or transfusion.

A

Anti-Lub

40
Q

number of amino acid for the longer Lu glycoprotein

A

597

41
Q

glyphorin proteins where MNSs antigen are attached

A

Sialoglycoprotein

42
Q

Considered to be the ancestral gene of MNSs

A

GYPA gene

43
Q

Yt antigen is sensitive to (3 pts)

A

Ficin, papain, dithiothreitol

44
Q

Dombrock antigen is sensitive to

A

Dithiothreitol

45
Q

gene location of Ch-Rg genes

A

chromosome 6p21.3

46
Q

The Antigens are well developed at birth but are absent from patients with Paroxysmal Nocturnal Hemoglobinuria

A

Cartwright “Yt”

47
Q

present in 97-98% of most populations

A

Rg

48
Q

first reported in 1973
Present on RBCs of 4% of Indians, 11% of Iranians,

A

Inª

49
Q

Found on RBCs and some tissues but NOT in secretions

A

MNSs

50
Q

Comprised of 6 high-prevalence antigens and 5 low-prevalence antigens

A

Gerbich

51
Q

antibody was found in the serum of a Lupus erythematosus patient

A

Lutheran “Lu” ISBT #005

52
Q

Sometimes IgM but are usually IgG and reacts at IAT

A

Diego Antibodies

53
Q

The gene which encodes the Diego antigens

A

SLC4A1

54
Q

Knops is unique because it is located on

A

Complement Receptor 1, CR1

55
Q

Knops antibody that is common in blacks

A

. Anti-S1ª

56
Q

MNSs gene is located at

A

chromosome 4q28-31

57
Q

MNSs was discovered by:

A

Landsteiner and Levine in 1927

58
Q

when was Dombrock Blood group first discovered

A

1965

59
Q

found on the short arm of the
X chromosome and is of higher prevalence in females
(89%) than in males (66%).

A

Xga antigen

60
Q

a 78 kD protein with a shorter cytoplasmic domain

A

Shorter basal cell adhesion molecule

61
Q

carries the Dombrock antigens

A

mono-ADP-ribosyltransferase 4

62
Q

glycosylphosphatidylinositol-linked RBC glycoprotein,

A

acetylcholinesterase

63
Q

Composed of 22 antigens, of three sets of independent pairs of antithetical antigens and 17 low-prevalence antigens

A

Diego

64
Q

Year Gerbich became a system

A

1990

65
Q

The antigens are carried on the Sialoglycoprotein structures Glycophorin C and
Glycophorin D.

A

Gerbich

66
Q

The antigens are expressed on cord RBCs

A

Scianna

67
Q

antigen location of Indian blood group

A

CD44 adhesion molecule

68
Q

Used in paternity testing

A

MNSs

69
Q

Can cause mild HDFN and delayed HTR

A

Dombrock antibodies

70
Q

high prevalence Scianna antigens

A

Sc5 (STAR)
Sc6 (SCER)
Sc7 (SCAN)

71
Q

antigens produced by codominant alleles; they are poorly developed at birth.

A

Lua and Lub

72
Q

Usually IgG and can be naturally occurring; Does not cause HDFN or HTRs

A

XG Antibodies

73
Q

RBC adhesion protein coded by SC gene

A

ERMAP (Erythroid Membrane Associated Protein)

74
Q

Yt gene location

A

chromosome 7q22

75
Q

gene (ART4) are found at chromosome 12p12.3

A

Dombrock

76
Q

causes severe HDFN

A

Anti-Co3

77
Q

Diego antigens are carried on

A

Band 3, Red Cell Anion Exchanger, “Solute carrier family-4”

78
Q

coded by MIC2 located at Xp22.2

A

CD99

79
Q

Which antigen is similar to Lewis in that it is absorbed onto the RBC?

A

Chido-Rodgers anigens

80
Q

Usually IgG; Not common; Often present with other antibodies

A

Dombrock antibodies

81
Q

Indian Blood group gene

A

CD44

82
Q

Observed in renal patients where dialysis machine is sterilized with formalin

A

Anti-N

83
Q

Explain what is antithetical

A

a pair of antigen that are coded by different alleles of a single gene

84
Q

a highly prevalent antigen identified on RBCs from two Co(a-b-) phenotypeindividuals

A

Co4

85
Q

number copies per RBC of XG glycoprotein

A

9000

86
Q

A rare antibody that reacts withall RBCsexcept Lu(a-b-) RBCs

A

Anti-Lu3

87
Q

Which antigen is located on the C4d component of complement?

A

Chido-Rogers (Ch and Rg)

88
Q

Presence of the Antigen of this blood system in the placenta contributes to its ability to decrease the likelihood of HDFN via adsorption

A

Lutheran

89
Q

M and N are easily destroyed by enzymes

A

Ficin, Papain, Bromelin, Trypsin, and Pronase)

90
Q

The long amino-terminal domain of Diego’s band 3 interacts with ___ and ____ of the membrane skeleton

A

ankyrin and protein4.2

91
Q

Binds complement and can cause HDFN and HTR with hemoglobinuria

A

AntiS and s

92
Q

appears with other specificities and also causes HTR andHDFN

A

Anti-Coᵇ

93
Q

Antibody that Can cause HDFN and HTR, and decreased Red Cell survival

A

Anti-U

94
Q

from the serum of a multiply transfused man

A

XG

95
Q

Yt antigens are antithetical and represent an amino acid substitution on this glycoprotein

A

Acetylcholinesterase

BB Quiz1 Semi (5 decks)

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