Quiz 1 Semis Flashcards by Hagar Grace

This antigenic integral membrane glycoprotein crosses the RBC membrane multiple times

Aquaporin 1 -

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Acquired hematopoietic stem cell disorder that results from the absence or deficiency in expression of GPIlinked proteins

Paroxysmal Nocturnal
Hemoglobinuria

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Yt weak immunogen antibody

Anti-Ytᵇ

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Both Doª and Doᵇ genes are codominant alleles that differs in ____ nucleotide
positions

three

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3 phenotypes of Cartwright

Yt(a+b-), Yt(a+b+), Yt(a-b+)

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Observed from multiparous women ; common in children&patients w/ Bacterial infection

Anti-M

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antigens are not intrinsic to the RBC membrane

Chido-Rodgers

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Rare in most populations but is more polymorphic in people of Mongoloid ancestry

. Diª

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antibodies Can be significant in transfusion

Gerbich

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Lutheran system is composed of how many antigens

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Neutralization with pooled plasma is used to identify this antibodies

Chido-Rodgers

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high prevalence antigen in all populations

Yta

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Who discovered antigen S and s

Discovered in 1947 by Walsh and Carmel Montgomery

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Which antigens are formed on Glycoprotein C and D, similar to MNS? These contribute to what 2 aspects of the RBC?

Gerbich antigens (Ge)
Membrane integrity and negative charge

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Causes immediate HTR

Indian Antibodies

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IgM and are naturally occurring saline agglutinins

Anti-Luª

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Found on RBCs of all individuals except about 1% of African Americans

U (MNS5)

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Anti-N lectins

Vicia graminea
Bauhinia variegata
Bauhinia purpura

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G from XG blood group was named after

Grand Rapids where the patient was treated

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Named after the first antibody maker from a Venezuelan family during an investigation of HDFN

Diego

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Reacts at room temperature and some can bind complement; Causes delayed HTRs

Anti-Luª

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Have a prevalence of more than 90% in most populations

Knops antigen

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Lu antigens are important for

adhesion properties
mediation of intracellular signaling

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gene location of Indian Blood Group

Chromosome 11p13

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The Scianna antigens are resistant to ___ and ___, and are weakened by ______

ficin and papain Dithiothreitol

Single nucleotide mutation in Yt gene causes an amino acid change at position

353

Discovered U antigen

Weiner

gene(CR1) responsible for the group is at chromosome1q32

Knops

Not present on other blood cells but are detected in other tissues such as the brain, lungs, pancreas, placenta, skeletal muscle, and hepatocytes

Lutheran Antigens

Lutheran antigens are located on

type 1 transmembrane protein

The antigens are on the fourth component of C4 and are just adsorbed to the RBCs from the plasma

Chido-Rodgers

has threonine at position 117

Joseph (Jo^a)

GPA and GPB are also expressed in (2 pts)

renal endothelium an epithelium

Reacts with DAT;

Dombrock antibodies

only group associated with a complement protein

Chido-Rodgers

The gene that codes for the antigen is the aquaporin 1 (AQP1)

Colton

What antibody can be found in multiply transfused patients, like those with thalassemia or sickle cell?

Anti-Kna (Knops)

Detected on fetal RBCs as early as 10-12 weeks of gestation but are poorly developed at birth

Lutheran Antigens

an IgG antibody reactive at the antiglobulin phase; it is usually produced in response to foreign RBC exposure during pregnancy or transfusion.

Anti-Lub

number of amino acid for the longer Lu glycoprotein

597

glyphorin proteins where MNSs antigen are attached

Sialoglycoprotein

Considered to be the ancestral gene of MNSs

GYPA gene

Yt antigen is sensitive to (3 pts)

Ficin, papain, dithiothreitol

Dombrock antigen is sensitive to

Dithiothreitol

gene location of Ch-Rg genes

chromosome 6p21.3

The Antigens are well developed at birth but are absent from patients with Paroxysmal Nocturnal Hemoglobinuria

Cartwright "Yt"

present in 97-98% of most populations

first reported in 1973 Present on RBCs of 4% of Indians, 11% of Iranians,

Inª

Found on RBCs and some tissues but NOT in secretions

MNSs

Comprised of 6 high-prevalence antigens and 5 low-prevalence antigens

Gerbich

antibody was found in the serum of a Lupus erythematosus patient

Lutheran "Lu" ISBT #005

Sometimes IgM but are usually IgG and reacts at IAT

Diego Antibodies

The gene which encodes the Diego antigens

SLC4A1

Knops is unique because it is located on

Complement Receptor 1, CR1

Knops antibody that is common in blacks

. Anti-S1ª

MNSs gene is located at

chromosome 4q28-31

MNSs was discovered by:

Landsteiner and Levine in 1927

when was Dombrock Blood group first discovered

1965

found on the short arm of the X chromosome and is of higher prevalence in females (89%) than in males (66%).

Xga antigen

a 78 kD protein with a shorter cytoplasmic domain

Shorter basal cell adhesion molecule

carries the Dombrock antigens

mono-ADP-ribosyltransferase 4

glycosylphosphatidylinositol-linked RBC glycoprotein,

acetylcholinesterase

Composed of 22 antigens, of three sets of independent pairs of antithetical antigens and 17 low-prevalence antigens

Diego

Year Gerbich became a system

1990

The antigens are carried on the Sialoglycoprotein structures Glycophorin C and Glycophorin D.

Gerbich

The antigens are expressed on cord RBCs

Scianna

antigen location of Indian blood group

CD44 adhesion molecule

Used in paternity testing

MNSs

Can cause mild HDFN and delayed HTR

Dombrock antibodies

high prevalence Scianna antigens

Sc5 (STAR) Sc6 (SCER) Sc7 (SCAN)

antigens produced by codominant alleles; they are poorly developed at birth.

Lua and Lub

Usually IgG and can be naturally occurring; Does not cause HDFN or HTRs

XG Antibodies

RBC adhesion protein coded by SC gene

ERMAP (Erythroid Membrane Associated Protein)

Yt gene location

chromosome 7q22

gene (ART4) are found at chromosome 12p12.3

Dombrock

causes severe HDFN

Anti-Co3

Diego antigens are carried on

Band 3, Red Cell Anion Exchanger, “Solute carrier family-4”

coded by MIC2 located at Xp22.2

CD99

Which antigen is similar to Lewis in that it is absorbed onto the RBC?

Chido-Rodgers anigens

Usually IgG; Not common; Often present with other antibodies

Dombrock antibodies

Indian Blood group gene

CD44

Observed in renal patients where dialysis machine is sterilized with formalin

Anti-N

Explain what is antithetical

a pair of antigen that are coded by different alleles of a single gene

a highly prevalent antigen identified on RBCs from two Co(a-b-) phenotypeindividuals

Co4

number copies per RBC of XG glycoprotein

9000

A rare antibody that reacts withall RBCsexcept Lu(a-b-) RBCs

Anti-Lu3

Which antigen is located on the C4d component of complement?

Chido-Rogers (Ch and Rg)

Presence of the Antigen of this blood system in the placenta contributes to its ability to decrease the likelihood of HDFN via adsorption

Lutheran

M and N are easily destroyed by enzymes

Ficin, Papain, Bromelin, Trypsin, and Pronase)

The long amino-terminal domain of Diego's band 3 interacts with ___ and ____ of the membrane skeleton

ankyrin and protein4.2

Binds complement and can cause HDFN and HTR with hemoglobinuria

AntiS and s

appears with other specificities and also causes HTR andHDFN

Anti-Coᵇ

Antibody that Can cause HDFN and HTR, and decreased Red Cell survival

Anti-U

from the serum of a multiply transfused man

Yt antigens are antithetical and represent an amino acid substitution on this glycoprotein

Acetylcholinesterase