WBC Shit

Question 1

Immature Nphil/L Shift CD Marker

Answer 1

16

Question 2

Granulocyte Finding in HL

Answer 2

Eosinophilia from IL5

Question 3

Granulocyte Finding in CML

Answer 3

Basophilia

Question 4

Marker for Lymphoblast

Answer 4

TdT

Question 5

Marker for Myeloblast

Answer 5

MPO/Auer Rod (AML)

Question 6

Down Syndrome Associations

Answer 6

5 ALL

Question 7

B-ALL 3 Surface Markers

Answer 7

CD10, 19, 20

Question 8

2 B-ALL Cytogenetics

Answer 8

t(12:21) - kids, good px

t(9:22) - poor px, adults

Question 9

T-ALL Markers

Answer 9

B/w 2-8, not 10

Question 10

T-ALL Presentation

Answer 10

Thymic mass in teenager

Question 11

APL (cytogen and ds)

Answer 11

t(15:17). Disrupts retinoic acid R, promyelocytes accumulate. Lots of Auer rods -> DIC bc activate coag cascade. Treat with ATRA which binds RAR and allows to mature

Question 12

Acute Monocytic Leukemia (2)

Answer 12

Don’t express MPO (like acute megakaryoblastic)

Invade gums

Question 13

Myelodysplastic Syndrome

Answer 13

Cytopenias from dysplasia, hypercellular BM but blasts 20%

Question 14

CLL (what it is, markers, smear)

Answer 14

Prolif of naive Bcs
Co-express CD5 and 20 (5 notable bc usually Ts)
Increased lymphocytes and smudge cells on smear

Question 15

Hairy Cell Leukemia (what it is, marker)

Answer 15

Prolif of mature Bs

Presence of TRAP (trapped in red pulp, BM, so can’t get to LN so no LAD)

Question 16

2-CDA

Answer 16

Adenosine deaminase inhibitor, builds up and is toxic to Bs. Excellent for Hairy Cell