Leukemias

Question 1

Age Distribution of 4 Leukemias

Answer 1

AML: Bimodal, old>young
CML: YA/MIDDLE AGE
ALL: Bimodal, young>old
CLL: Elderly

Question 2

2 Surface Markers AML

Answer 2

13/33

Question 3

2 Surface Markers ALL

Answer 3

10, TdT

Question 4

4 Surface Markers CLL

Answer 4

CD5 and 20 (B cell)

Question 5

3 Good Px Genes for AML

Answer 5

t(15:17)
Inv 16
t(8:21)

Question 6

CML Gene

Answer 6

t(9:22) Ph - Bcr-abl

Question 7

Bad Px Gene ALL

Answer 7

t(9:22)

Question 8

Bad Px Gene CLL

Answer 8

17p del bc p53

Question 9

Blasts for 4 Leukemias

Answer 9

AML: Super high
CML: Maybe some, whole spectrum of stuff
ALL: High
CML: None

Question 10

Important AML FAB Type

Answer 10

M3: APL

Question 11

Basophilia Ds

Answer 11

CML

Question 12

4 Leukemias Rx

Answer 12

AML: Immediate Induction chemo/consolidation
CML: TKI - imatinib
ALL: Induction/consolidation/maintenance (long) w/ CNS prophylaxis
CLL: Observation, maybe some other therapies

Question 13

4 Leukemias Transplant

Answer 13

AML: Yes high risk CR1, all CR2
CML: Rare
ALL: Yes depending on age/further CRs
CLL: No

Question 14

4 Leukemias Curability:

Answer 14

AML: All right, better with transplant
CML: No
ALL: 90% children (chemo), 45% adults
CLL: No

Question 15

CLL Hallmark

Answer 15

Immunosuppression and Ig on RBCs

Question 16

4 Leukemias Smear:

Answer 16

AML: Big cells w/ Auer rods
CML: Shitload WBCs, all stages of maturation (maybe Auers?)
ALL: Blasts, no maturation or hour rods
CLL: WBCs look same/mature but small

Question 17

Myelofibrosis Smear Finding

Answer 17

Leucoerythroblastic Anemia

Question 18

MDS Clinical Finding

Answer 18

Refractory anemia and pancytopenia

Question 19

MDS Good Px Mut

Answer 19

5q- responds well to lenalidamide

Question 20

ET Tx

Answer 20

Hydroxyurea (Ruxolitinib too)