Platelet Shit

Question 1

MPN

Answer 1

Acquired (only) thrombocytosis

Question 2

Carrier for FVIII

Answer 2

vWF

Question 3

Thrombin Time Function

Answer 3

Put thrombin in, measure fibrinogen->fibrin. Maybe to look for DIC?

Question 4

Vitamin K

Answer 4

Catalyzes Carboxylation of II, VII, IX, and X and Protein C and S

Question 5

Prot C and S Functions

Answer 5

Inactivate cofactors VIII and V

Question 6

2 Newer Anticoags

Answer 6

Direct Factor X inhibitors - “-aban”

Direct thrombin inhibitor - not reversible. Dabigatran

Question 7

Lupus Anticoagulant

Answer 7

Can interfere with and prolong PTT without higher risk of bleeding. Can be part of more severe anti-phospholipid syndrome

Question 8

Recurrence/Tx after VTE

Answer 8

Provoked: 3 months, 5-10% long term recurrence
Idiopathic: 30% long term, anticoag forever or 5% per year

Question 9

3 Most Numerous Transplant Diseases/What Kind

Answer 9

MM - Autologous, not a cure but prolonged remission
NHL - relapse? autologous
AML - allogeneic

Question 10

Aplastic Anemia Tx

Answer 10

Severe in young patients w/ donors, transplant