WBC - Neoplastic Markers Flashcards
1
Q
ALL markers
A
Pre-B:
- TdT
- EARLY B CELL ANTIGENS: cCD22, CD19, CD10, CD79a
- Surface light chain negative
Pre-T:
- EARLY T CELL ANTIGENS: CD1a, CD2, CD5, CD7
- OTHER ANTIGENS: cCD3, CD4, CD8
2
Q
CLL/SLL markers
A
- CD19, CD5, CD23
- Dim CD20 and dim surface light chain
3
Q
Follicular lymphoma markers
A
- CD19, CD20, CD10
- Bright surface light chain
- bcl2 +
- bcl6 +
4
Q
Mantle cell lymphoma markers
A
- CD19, CD20, CD5
- Bright CD20 and surface light chain
- CD23 negative
5
Q
Marginal zone lymphoma markers
A
- Nothing Specific: CD19, CD20, surface light chain
6
Q
Hairy cell leukemia markers
A
- CD19, CD20, surface light chain restriction
- CD11c, CD25, CD103
7
Q
Diffuse large B-cell lymphoma markers
A
- CD19, CD20
- Surface light chain restriction
- +/- bcl2, CD10
- +/- bcl6
8
Q
Burkitt lymphoma markers
A
- CD19, CD20, CD10
- Surface light chain restriction
- bcl6
- No bcl2 or immature markers (CD34 or TdT)
9
Q
Anaplastic large cell lymphoma markers
A
- CD30 +
- EMA +
- ALK +
NEGATIVE ALK WHEN IN ADULTS
10
Q
Adult T-cell leukemia/lymphoma markers
A
- CD4 +
- CD7 -
- HTLV1 +
11
Q
Hodgkin lymphoma markers
A
Classical:
- CD15 +
- CD30 +
- Negative for CD45, B and T cell antigens
Nodular Lymphocyte Predominance:
- B cell antigen +
- CD45 +
- bcl6 +
- Negative for CD15 and CD30
12
Q
AML markers
A
Myeloblast:
- CD34, CD13, CD33
- MPO +
- Negative NSE
Monoblast:
- CD11b, CD14, HLADR
- NSE +
- Negative MPO
13
Q
Follicular lymphoma translocation
A
t(14;18)
14
Q
Burkitt lymphoma translocation
A
t(8;14)
15
Q
Mantle cell lymphoma translocation
A
t(11;14)
