WBC (Malignant)

Question 1

Fatal systemic disease characterized by ________

Answer 1

excessive proliferation of clone of immature blood

Question 2

Derived from hematopoietic stem cells

Answer 2

Leukemia

Question 3

Immature blast cells are accompanied by

Answer 3

anemia and thrombocytopenia

Question 4

specific names depends on the following

Answer 4

-tissue which they are found
-cells they are associated
-definitive cells they are produce

Question 5

Etiology of leukemia

Answer 5

-radiation
-chemicals
-genetics/familial disease
-viruses
-primitive immune defects
-myeloproliferative disorders

Question 6

oncogene

Answer 6

encodes protein vital in signal transduction, induction of cancer

Question 7

chromosomal aberration including aneuploidy and breakage down syndrome

Answer 7

trisomy 21

Question 8

excessive chromosomal breakage

Answer 8

fanconi sysndrome

Question 9

marked chromosal breakage and arrangement

Answer 9

bloom syndrome

Question 10

viruses uses enzyme

Answer 10

reverse transcriptase

Question 11

associated with burkitt lymphoma and IM

Answer 11

Epstein barr virus

Question 12

associated with T cell leukemia and lymphoma

Answer 12

Human t cell lymphototorphic virus

Question 13

proto oncogenes

Answer 13

c-abi and c-sis

Question 14

according to age
acute leukemia
chronic lymphocytic
Chronic grabulocytic

Answer 14

below 20
more than 50
20-50

Question 15

resting lymphocte

Answer 15

-low level of dna replication
-poor host for many virus
-gene expression regulated

Question 16

dividing lymphocyte

Answer 16

-high dna replication
-susceptible to potentially
-loss of control over gene expression

Question 17

Laboratory findings
L1

Answer 17

variable wbc count < 20x10^9/L

Question 18

Laboratory findings
L2

Answer 18

elevated wbc count > 20x10^9/L

Question 19

Laboratory findings
L3

Answer 19

normal and elevated wbc count

Question 20

MPAL

Answer 20

mixed phenotype acute leukemia

Question 21

chronic disorder characterized by lymphadenopathy and infiltration of BM and PS by mature lymphocyte

Answer 21

CLL

Question 22

most common type of leukemia in western world

Answer 22

CLL

Question 23

BINET staging system for CLL
STAGE A

Answer 23

no anemia and thrombocytopenia less than 3 lymphoid areas

Question 24

BINET staging system for CLL
STAGE B

Answer 24

no anemia and thrombocytopenia more than 3 lymphoid areas

Question 25

BINET staging system for CLL STAGE C

Answer 25

Anemia hb less than 100 g/L and PLT less than 100x10^9

Question 26

signaling molecule used as surrogate marker for IgVH

Answer 26

ZAP70

Question 27

wait and see approach

Answer 27

CLL

Question 28

long standing given intermittently

Answer 28

Chlorambucil

Question 29

6 courses

Answer 29

Fludarabine

Question 30

progressive disease which abnormal cells accumulate

Answer 30

CLL

Question 31

CLL lab finidng

Answer 31

absolute lymphocytosis in blood and lymphocytosis in marro2

Question 32

smudge cells present in

Answer 32

CLL

Question 33

LDT

Answer 33

blood lymphocyte doubling time

Question 34

transformation of CLL to a large lymphoma, a rapid progressing lethal disease occur in 3-15% with CLL

Answer 34

Richter syndrome

Question 35

Variant of CLL describe by Glaton

Answer 35

Prolymphocytic Leukemia

Question 36

marked lymphocytosis, prominent splenomegaly without sig lymphadenopathy

Answer 36

Prolymphocytic Leukemia

Question 37

lab finding in PLL

Answer 37

b cell prolymphocytes, t cell prolymphocytes, WBC count >400,000 . Hgb <12

Question 38

variant of CLL, represents the leukemic phase of folicular or diffuse small, celaved cell lymphoma

Answer 38

Lymphosarcoma Cell Leukemia

Question 39

slow progression, splenomegaly, pancytopenia, dry tap

Answer 39

Hairy Cell Leukemia

Question 40

monoclonal antibody give positive reaction with hairy cells

Answer 40

DBA 44

Question 41

predominance of primitive undifferentiated leukocyte

Answer 41

stem cell leukemia

Question 42

neoplastic proliferation of one cell types of lymphopoietic reticular tissue

Answer 42

malignant lymphoma

Question 43

4 types based in the extent of lymphocyte infiltration and abundance of reed sternberg

Answer 43

Rye classsification

Question 44

similar with rye except for further breakdown of stage III

Answer 44

Ann Arbor Staging system

Question 45

based on tumor growth pattern

Answer 45

rapoport classification

Question 46

an indolent and includes extranodal tumours like malt

Answer 46

Marginal zone lymphoma

Question 47

heterogenous but typically disseminated with marrow involvement

Answer 47

mantle cell lymphoma