WBC Flashcards
larger then rbc, nucleated
leukocyte
malignant proliferation of wbc producing cells
leukemia
increase wbc
leukocytosis
decrease wbc
leukopenia
turnover time of labeled compartment
grain count halving time
principle: difference in size and density allow the separation of formed elements
leukocyte fractionation
formation of life span of neutrophil
9-10 days from myeloblast to death
separates particles in similar density
zonal sedimentation
separates particles in similar sizes
zonal centrifugation
not capable of mitosis
metamyelocyte
undergo cell division
myeloblast, promyelocyte and myelocyte
contains about 15 times band and segmenters
storage pool> peripheral blood
insinuate themselves through the walls of capillaries bet. endothelial cell
diapedesis
neutrophils, distinct asymmetric shape
hand mirror
glass mirror formed by pseudopod and called
lamellopod
one of the two x chromosomes in the cell of a female become in active, what process?
lyon hypothesis
expressed in neutrophil used to detect hidden infection
cd15
condensation of chromatin below nuclear membrane
barr body
avidity binds to neutrophil
wistar antibody
neutrophils containing small and dark gray inclusion
ragocytes
ability of neutrophil to sense presence of particulate
chemotaxis or leukotaxis
undefined neutrophil defect
reduced adhesion and migration
lazy leukocyte syndorme
-random movement is normal and directional
-motility is impaired
-response with boils
job syndrome
glycoprotein found in plasma and outer membrane fibrolast
fibronectin
-opsonins are components of fresh serum that coat foreign particle
-act upon bacteria to make them tasty
opsonization
fusion of phagocytic vacuole with lysosome
degranulATION
failure of granule release
chediak higashi
inability to ingest organism
congenital c3 deficiency
chronic granulomatous disease
defect in oxidative metabolism
impairs hms, unable to produce respiratory burst
g6pd
absent only in neutrophil and monocyte
normal in eosinophil
severe candida infection
myeloperoxidase ediciency
cyclic neutropenia recurring within cycle of
19-21 days
derived from single precursor cell with all the affected cell (progeny)
clonal disorder
stable protein that serves marker for leukocyte
lactoferrin
knapsack shaped nucelus
eosinophil
eosiniphil can be found in tissues such as
skin
other epithelial barriers
intestinal tract
lungs
“SOIL”
eosinophil spend ___ in circulation , ___ in production
8 hrs, 3-6 days
excellent stain to demonstrate eosinophil in eosinophiluria
hansel secretion stain
charcot-leyden crystals composed of
lysophospholipase
allergic angitis an granulomatosis
churg-strauss syndrome
basophils matures in
7 days
sluggish locomotion and phagocytosis
basophil
produced by t-lymphocyte for recruitment from circulation to sites of allergic reaction
basophilopoietin
cytochemical reaction can be used to identify basophils
epsilon-aminocaproate
monocyte enters circulation for
18 hrs
monocyte remains in the blood fro approx.
3 days
involve in nursing or suckling phenomenon
monocyte
___ receptor on macrophage binds ___ and aid in adhesion
CR 1 , C3 b
monocytic leukocytosis infection bacterial : tb secretes __
dihydrolipoamide acyl transferase
promotes maturation of t-lymphocyte
thymosin
pre-thymocyte and thymocyte process TdT
terminal deoxynucleotidyl transferase
t-lymphocyte develops in
thymus
t lymphocyte develops surface antigen
theta antigen
lymphocyte that remains programmed
memory cells
program a population of b-lymphocyte
helper cells
cooperates GVH reactive t cells
Th (amplifier cells)
limit the immunologic activity of other lymphocyte
suppressor cells
respond to particulate and soluble antigens by producing chemotactic lymphokines
Delayed Hypersensitivity T-lymphocyte
regulate suppressor and helper t cells
activator cells
blocks the reproduction of viruses
interferon
secreted by leukocytes upon exposure
alpha interferon
secreted by fibroblasts
beta interferon
secreted by lymphoid cells
gama interferon
kills targets cells, and foreign substances and causes tissue damage
lymphokines
directs movement of macrophage, monocyte and granulocyte
chemotactic factor
defective development of lymphoid thymus
Nezelof syndrome
not a genetic origin but may result from intrauterine infection
Di george syndrome
infantile sex linked agamma
brutons agammaglobulinemia
other name for B lys S
TALL 1
loss both t and b function
swiss type agammaglobulinemia
failure to generate adequate t cell response
wiskott aldrich
ataxia telaengiectasia
dilation of small blood vesssels
immunosurveillance against tumor cells
natural killer cell
lymphocytotoxicity test measuring the degree of antibody reactivity
PRA percent reactive antibody
plasma cell labeling index
2 bromo 2 deoxyuridine
to detect dohle bodies
non cytochemical satin
pappenheim methyl green pyronine stain
to detect true reticulum fibers and stroma cells
gomori silver-gold impregnation
used to rule in ALL
PAS and ORO
used to rule in granulocytic leukemia
SBB, MP, D-CI-E
used to distinguish CML from other leukocutosis
NAP
rule in hairy cell leukemia
ACP
absolute basophil count
to distinguish between progranuclocyte and basophils
toluidine blue method
copper & cruickshank method
lyse erythrocyte and render basophilic granules
cetylpyrimidium chloride
used as mordant
aluminum sulfate
associated with gargoylism
alder-reilly anomaly
rodlike structure in cytoplasm of monoblast and myeloblast
aur bodies
irregularly size inclusion bodies, cerulean blue areas in cytoplasm of PMN
Dohle-Amato bodies
prsence of fat containing vacuoles
jordan anomaly
presence of inclusion in pmn and monocyte
may-hegglin anomaly
failure of nucleus of neutrophil to lobulate
pelger-huet
degenerating or ruptured wbc
smudge/basket cell
due to erlichiosis infections
basophilic morule body
sex-linked recssive (disease of male infants)
Chronic granulomatous Disease
lymphocyte with thread like projection
hairy cells
maturation off nautrophil causing macropolycytes
undritz anomaly
generally specific for SLE
Anti Native DNA and anto- Sm
SnRNP
containd uracil