Wbc Lymph Node Spleen

Question 1

Most common leukemia of western adults

Answer 1

CLL SLL

Question 2

Most common indolent lymphoma

Answer 2

Follocular lymphoma

Question 3

Most common lymphoma of adults most common NHL

Answer 3

Diffuse large b cell lymphoma

Question 4

Fastest growing human tumor

Marker

Answer 4

Burkitts lumphoma ki 67

Question 5

Most common cancer of children

Answer 5

Acute lymphoblastic leukemia

Question 5

B cell acute lymphoblastic leukemia mutation

T cell acute lymphoblastic lymphoma mutation

Immunohisto stain

Answer 5

BALL : t(12:21) ETV6 RUNx gene

TALL : NOTCH1 gene

Tdt + MPO-

Question 6

Chronic Lymphocytic leukemia

Mutation

Pathog

Answer 6

Deletion 13, 11, 17, Trisomny 12

Proliferation centers

Question 7

Follicular lymphoma

Mutation

Pathog

Answer 7

BCL2 gene t (14:18)

Centrocytes
Centroblasts

Question 8

Diffuse large b cell lymphoma

Mutation (3)

Common clinical finding

Answer 8

BCL6 gene 3q27

BCL2 gene t(14;18)

MYC gene on chromosome 8

Rapidly enlarging LN and spleen

Question 9

Burkitt lymphoma

Mutation which allows ______

Pathogn

Which type is EBV 100%

Answer 9

MYC gene on chromosome 8, warburg effect

Starry sky: stars macrophage, sky apoptotic b cells

Endemic

Question 10

Mantle cell lymphoma

Mutation

Clinically similar to a and b due to ________

Differentiate mantle cell lymphoma and a and b with pathogn.

Answer 10

IgH locus t (11:14)

Chronic lymphocytic leukemia and follicular lymphoma, generalized lymphadenopathy

NO proliferation centers, no centroblasts respectively

Question 11

Marginal Cell lymphoma

Patho of EXTRA NODAL

Mutation

Answer 11

Chronic inflammation secondary to
Ss, hashimoto, H. Pylori

BCL10,

Question 12

Hairy Cell Leukemia

Where are hairy cells seen?

Answer 12

Red pulp of spleen “splenic sequestration”

Question 13

Anaplastic large cell lymphoma

Mutation

Pathogn.

Location

Answer 13

ALK1 gene on 2p23

Hallmark cell

Lymphoid sinuses (Like mets)

Question 14

Adult T cell lymphoma

Pathogenesis

Pathogn.

Vs Multiple myeloma

Answer 14

Cd+4 infected by Human t cell leukemia virus type 1 = nfkb 1

Cloverleaf / flower cells

Both can have lytic lesions and hypercalcemia but this has skin lesions

Question 15

Mycosis fungoides, sezary syndrome

Pathology

Pathogn.

Mycosis vs sezary.

Answer 15

CD+4 cells of SKIN

Butt / cerebriform nuclei

Exfoilative erythroderma

Question 16

Hodgkin lymphoma

Pathology seen in?

Immuno stain

Answer 16

Axial LN

Cd15, CD30

Question 17

Hodgkin lymphoma

ann arbor I,II most common type and RS cell

Clinical

Associated with what virus??

Answer 17

Nodular sclerosis : lacunar cell + fibrous bands

Lymphocyte predominant : popcorn cell

Mediastinal involvement

No EBV

Question 18

Hodgkin lymphoma

Ann arbor III, IV usual type and RS type

Associated with what virus?

Answer 18

Mixed cellular : mononuclear, with many cells in background

Lymphocyte depleted : mononuclear no lymphocytes

EBV LD > MC

Question 19

Acute myeloid leukemia

Most common mutation

Best prognosis mutation (name)

Worst prognosis mutation, WHO class

Answer 19

t(8:21) RUNx1

t(15;17) FABm3, retinal receptor acute promyelogenous leukemia

Therapy associated leukemia, WHO class III chromosome 5,7 deletion

Question 20

Acute myeloid leukemia

Pathogn. Cell of t(______) mutation

Answer 20

Faggot cells, with auer rods t(15;17)

Question 21

Chronic myelogenous leukemia

Mutation

Mutation also seen in ______

Answer 21

T(9;22) BCR ABL
Philadelphia chromosome

Acute lymphoblastic leukemia