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Pathology Review > Acute And Chronic Inflammation > Flashcards

Acute And Chronic Inflammation Flashcards

1
Q

Margination molecules involves?

A

selectins

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2
Q

Rolling molecules involves?

A

Integrins

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3
Q

Upregulation of

  1. P selectins
  2. E selectins
A
  1. P selectins histamine IL-1 TNF

2. E selectins IL-1 TNF

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4
Q

Upregulation of integrins

  1. On leukocyte
  2. On endothelial cells (ICAM and VCAM)
A
  1. C5a, LTB4

2. TNF IL1

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5
Q

Molecules invovled in chemotaxis? (X3)

A
  1. IL8
  2. LTB4
  3. C5a
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6
Q

Molecules in Diapedisis?

A

PECAM-1 CD31

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7
Q

Molecules in the downregulation of inflammation?

A
  1. IL10
  2. TGF Beta
  3. Lipoxin
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8
Q

Most abundant component of the complement system?

A

C3 which gives rise to

C3a - anaphylatoxin
C3b - opsonin

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9
Q

Hereditary angioedema is caused by?

A

C1 inhibitor defiency

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10
Q

Paroxysmal nocturnal hemoglobinuria is caused by?

A

DAF + CD59 deficiency

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11
Q

Susceptibility Neisseria infection

A

Defects in late components

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12
Q

Hallmark of acute inflammation

A
  1. Leukocytes + fluid

2. Vasodilation of small vessels

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13
Q

Morphological characteristics of chronic inflammation

A
  1. Lymphocytes, plasma cells, monocytes
  2. Tissue destruction
  3. Attempts at repair (angiogenesis, fibrosis)
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14
Q

Labile tissues can undergo REGENERATION because?

A

The presence of epithelium and stem cells

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15
Q

Stable tissue can undergo REGENERATION because of the presence of?

A

Cells in teh G0 phase

Examples

  1. Liver
  2. Kidney
  3. Pancreas
  4. Endothelium.
  5. Smooth muscle, fibroblasts.
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16
Q

Permanent tissue cannot undergo regeneration, instead connective tissue deposition occurs due to?

A

Tissue is terminally differentiated already.

17
Q

The most important cytokine in scar formation?

A

TGF beta

18
Q

Granulation tissue the HALLMARK of repair is seen on average in around how many days?

A

3-5 days

Pathology Review (8 decks)

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