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1. USMLE > WBC/Bone Disorders and Neoplasms > Flashcards

WBC/Bone Disorders and Neoplasms Flashcards

0
Q

B-ALL

A

Tdt+
Cd10+ pre B cell only usmle
Cd19+
Cd20+

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1
Q

ALL

A

Now plastic proliferaction of blast >20%

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2
Q

ALL translocation

A

T12:21

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3
Q

T-ALL

A

Tdt+
Cd2-cd8+
Cd10-

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4
Q

All seen in?

And where is it found

A

Teens and thymus

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5
Q

AML

A

Neoplastic proliferation of myeloid stem cells >20% in bone marrow

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6
Q

AML M3

What is positive

A

Acute promyelocytic leukemia
Mpo+
Sudan b black stain +

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7
Q

M3 translocation

A

T15:17

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8
Q

T15:17

A

Translocation of retinoic acid receptor from ch 15 to ch 17

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9
Q

AML m3 treatment

A

All trans retinoic acid

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10
Q

Aml m5

A

Acute monocytic leukemia

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11
Q

Aml m5

And findings

A

Proliferation of mono blast
Mpo-
EsterAse+
Choloroma in gums

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12
Q

Aml m7

A

Acute megalaryoblastic leukemia

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13
Q

Associated with downs syn >5

A

All

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14
Q

Associated with downs syn <5

A

Aml m7

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15
Q

If blast >30%

A

Acute LL

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16
Q

If blast <30%

A

Chronic lymphocytic leukemia

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17
Q

Chronic lymphocytic leukemia

A

Neoplasm of naive B cell

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18
Q

CLL FINDINGS

A

Cd5+
Cd20+
Smudge cells

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19
Q

small lymphocytic lymphoma

A

CLL that’s involves the lymph nodes

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20
Q

Complication of CLL

A

Hypogammaglobins
Autoimmune hemolytic anemia igm or igg
Enlarged lymph nodes (richter transformation)

21
Q

Hairy cell leukemia

A

Neoplasm of mature B cell

22
Q

Hairy cell leukemia wha is positive

23
Q

Hairy cell leukemia treatment and its MOA

A

Cladribine

It’s a adenosine deaminase inhibitor

24
Adult T cell leukemia | Associations and clinical findings
Neoplastic proliferation of mature cd4 tcells. HTLV-1 Cf: rash, lytic punched out bone lesions with hyperca2+, big spleen,liver,lymph nodes
25
Rash + punched out bone lesion
Atll
26
Mycosis fungoides
Neoplasticism proliferation of cd4 th cell
27
Pautrier micro abscess seen in....
Mycoses fungoides | Are aggregates of neoplastic cells in epidermis
28
SezAry syndrome
Cd4 th cells that involve the blood
28
SezAry syndrome
Cd4 th cells that involve the blood
29
Myeloproliferative disorder | And it's complication
Proliferation of myeloid stem cells | Progress to marrow fibrosis or AML
29
Myeloproliferative disorder | And it's complication
Proliferation of myeloid stem cells | Progress to marrow fibrosis or AML
30
CML | Translocation And it's effect
9:22 | Bcr-abl fusion with tyrosine kinase activity.
30
CML | Translocation And it's effect
9:22 | Bcr-abl fusion with tyrosine kinase activity.
31
Cml treatment
Imatinab
31
Cml treatment
Imatinab
32
Reactive neutrophilic leukocytosis
Leukemoid reaction vs CML Lap + - Basophils - + 9:22 - +
32
Reactive neutrophilic leukocytosis
Leukemoid reaction vs CML Lap + - Basophils - + 9:22 - +
38
Follicular lymphoma aka small cleaved lymphoma
T14:18 Bcl2:ig heavy chain translocation
39
Mantle cell lymphoma
T11:14 Cyclind1:ig heavy chain Inc g1. To s phase
40
Marginal zone lymphoma aka maltoma
T11:18 | Associated with h.pylori
41
Burkits lymphoma
T8:14 Small non cleaved lymphoma Translocation of cmyc to ig heavy chain
42
Small non cleaved lymphoma is also called
Burkits lymphoma
43
Smallcleaved lymphoma is also called
Follicular lymphoma
44
Burkits African organ involvement American organ involvement
African involves the jaw | American ab,ovaries, pelvis (high yield)
45
Osteoid osteoma
Proximal femur Surrounded by sclerotic bone Painful relived by aspirin
46
Giant cell tumor | Aka osteolastoma
Location: distal end of femur proximal to tibia Soap bubble appearance on X-ray Multinuceated giant cells
47
Osteochondroma
Most common benign tumor also called exostosis mature bone wth cartilaginous cap males<25y.old
48
OsTeosarcoma
Predisposing factors: Paget disease of bone, bone infarcts, radiation, familial retinoblastoma, Li-Fraumeni syndrome (germline P53 mutation). Metaphysis of long bones, often around knee . Codmans triangle
49
Osteosarcoma location
Metaphysis of distal femur or proximal tibia
50
Ewing's sarcoma
Boys <15 At the diaphysis of long bone Onion skin appearance T11:22
51
Chondrosarcoma
At the diaphysis Malignant cartilaginous tumor. May be of 1° origin or from osteochondroma. Expansile glistening mass within the medullary cavity.

1. USMLE (7 decks)

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