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1. USMLE > WBC/Bone Disorders and Neoplasms > Flashcards

WBC/Bone Disorders and Neoplasms Flashcards

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USMLE® Step 1 flashcards
0
Q

B-ALL

A

Tdt+
Cd10+ pre B cell only usmle
Cd19+
Cd20+

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1
Q

ALL

A

Now plastic proliferaction of blast >20%

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2
Q

ALL translocation

A

T12:21

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3
Q

T-ALL

A

Tdt+
Cd2-cd8+
Cd10-

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4
Q

All seen in?

And where is it found

A

Teens and thymus

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5
Q

AML

A

Neoplastic proliferation of myeloid stem cells >20% in bone marrow

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6
Q

AML M3

What is positive

A

Acute promyelocytic leukemia
Mpo+
Sudan b black stain +

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7
Q

M3 translocation

A

T15:17

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8
Q

T15:17

A

Translocation of retinoic acid receptor from ch 15 to ch 17

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9
Q

AML m3 treatment

A

All trans retinoic acid

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10
Q

Aml m5

A

Acute monocytic leukemia

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11
Q

Aml m5

And findings

A

Proliferation of mono blast
Mpo-
EsterAse+
Choloroma in gums

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12
Q

Aml m7

A

Acute megalaryoblastic leukemia

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13
Q

Associated with downs syn >5

A

All

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14
Q

Associated with downs syn <5

A

Aml m7

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15
Q

If blast >30%

A

Acute LL

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16
Q

If blast <30%

A

Chronic lymphocytic leukemia

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17
Q

Chronic lymphocytic leukemia

A

Neoplasm of naive B cell

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18
Q

CLL FINDINGS

A

Cd5+
Cd20+
Smudge cells

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19
Q

small lymphocytic lymphoma

A

CLL that’s involves the lymph nodes

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20
Q

Complication of CLL

A

Hypogammaglobins
Autoimmune hemolytic anemia igm or igg
Enlarged lymph nodes (richter transformation)

21
Q

Hairy cell leukemia

A

Neoplasm of mature B cell

22
Q

Hairy cell leukemia wha is positive

A

TRAP+

23
Q

Hairy cell leukemia treatment and its MOA

A

Cladribine

It’s a adenosine deaminase inhibitor

24
Q

Adult T cell leukemia

Associations and clinical findings

A

Neoplastic proliferation of mature cd4 tcells.
HTLV-1
Cf: rash, lytic punched out bone lesions with hyperca2+, big spleen,liver,lymph nodes

25
Q

Rash + punched out bone lesion

A

Atll

26
Q

Mycosis fungoides

A

Neoplasticism proliferation of cd4 th cell

27
Q

Pautrier micro abscess seen in….

A

Mycoses fungoides

Are aggregates of neoplastic cells in epidermis

28
Q

SezAry syndrome

A

Cd4 th cells that involve the blood

28
Q

SezAry syndrome

A

Cd4 th cells that involve the blood

29
Q

Myeloproliferative disorder

And it’s complication

A

Proliferation of myeloid stem cells

Progress to marrow fibrosis or AML

29
Q

Myeloproliferative disorder

And it’s complication

A

Proliferation of myeloid stem cells

Progress to marrow fibrosis or AML

30
Q

CML

Translocation And it’s effect

A

9:22

Bcr-abl fusion with tyrosine kinase activity.

30
Q

CML

Translocation And it’s effect

A

9:22

Bcr-abl fusion with tyrosine kinase activity.

31
Q

Cml treatment

A

Imatinab

31
Q

Cml treatment

A

Imatinab

32
Q

Reactive neutrophilic leukocytosis

A

Leukemoid reaction vs CML
Lap + -
Basophils - +
9:22 - +

32
Q

Reactive neutrophilic leukocytosis

A

Leukemoid reaction vs CML
Lap + -
Basophils - +
9:22 - +

38
Q

Follicular lymphoma aka small cleaved lymphoma

A

T14:18
Bcl2:ig heavy chain translocation

39
Q

Mantle cell lymphoma

A

T11:14
Cyclind1:ig heavy chain
Inc g1. To s phase

40
Q

Marginal zone lymphoma aka maltoma

A

T11:18

Associated with h.pylori

41
Q

Burkits lymphoma

A

T8:14
Small non cleaved lymphoma
Translocation of cmyc to ig heavy chain

42
Q

Small non cleaved lymphoma is also called

A

Burkits lymphoma

43
Q

Smallcleaved lymphoma is also called

A

Follicular lymphoma

44
Q

Burkits
African organ involvement
American organ involvement

A

African involves the jaw

American ab,ovaries, pelvis (high yield)

45
Q

Osteoid osteoma

A

Proximal femur
Surrounded by sclerotic bone
Painful relived by aspirin

46
Q

Giant cell tumor

Aka osteolastoma

A

Location: distal end of femur proximal to tibia
Soap bubble appearance on X-ray
Multinuceated giant cells

47
Q

Osteochondroma

A

Most common benign tumor also called exostosis

mature bone wth cartilaginous cap

males<25y.old

48
Q

OsTeosarcoma

A

Predisposing factors: Paget disease of bone, bone infarcts, radiation, familial retinoblastoma, Li-Fraumeni syndrome (germline P53 mutation).
Metaphysis of long bones, often around knee .
Codmans triangle

49
Q

Osteosarcoma location

A

Metaphysis of distal femur or proximal tibia

50
Q

Ewing’s sarcoma

A

Boys <15
At the diaphysis of long bone
Onion skin appearance
T11:22

51
Q

Chondrosarcoma

A

At the diaphysis
Malignant cartilaginous tumor.
May be of 1° origin or from osteochondroma.
Expansile glistening mass within the medullary cavity.

1. USMLE (7 decks)

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