WBC Flashcards
leukocyte morphologic abnormality
- hyposegmented + hyperclumped
- “pince-nez” morphology
- mimics leukemoid reaction (shift to left)
Pelger-Huet Anomaly
leukocyte morphologic abnormality
- granulocytes have dark staining granules
- due to incomplete degradation of mucopolysaccharides
- associated with Hurler, Hunter, and Sanfilippo syndrome
Alder-Reilly Anomaly
leukocyte morphologic abnormality
- red needles in cytoplasm
- observed in blast cells in AML, especially APL
- faggot cells
Auer Rods
leukocyte morphologic abnormality
disorder in the production of myosin heavy chain type IIa
May-Hegglin Anomaly
leukocyte morphologic abnormality
Triad of May-Hegglin Anomaly
- Dohle-like Bodies
- Thrombocytopenia
- Giant Platelets
leukocyte morphologic abnormality
- light blue patches in cytoplasm of neutrophils
- RNA remnants
Dohle bodies
leukocyte morphologic abnormality
immature granulocytes in peripheral blood
shift to the left
lymphocyte morphologic abnormality
lymphocytes that exhibit reactive morphology
downey/turk cell
lymphocyte morphologic abnormality
- caused by pressure in smear prep.
- indicates nuclear fragility
- ⬆️ in CLL
basket/smudge cell
lymphocyte morphologic abnormality
- plasma cell with irregular cytoplasmic projections
- contain more immunoglobulins than normal plasma cells
- associated with multiple myeloma
- bright purple-red in Wright’s stain
Flame cell
lymphocyte morphologic abnormality
plasma cell with round globules
(also associated with multiple myeloma)
Grape/mott/rusell bodies
lymphocyte morphologic abnormality
lymphocyte with convoluted, cerebriform nucleus (assoc with sezary syndrome and mycoses fungoides)
sezary cell
most common type of leukemia in adults
acute myeloid leukemia
surface markers in AML
CD13, CD33, CD117
other name for FAB M4
Naegelli leukemia
other name for FAB M5
Schilling’s leukemia
other name for FAB M6
Di Guglielmo Syndrome
25-75% of childhood leukemia
Acute lymphoblastic leukemia
location of genetic abnormality in ALL
t(12;21)
cytochem stain for phospholipids and lipids
Sudan Black B
oncogene formed from chronic myelogenous leukemia
BCR-ABL1
chromosome associated from chronic myelogenous leukemia
Philadelphia chromosome [t(9;22)]
diff. of CML and leukemoid reactions
CML has low NAP/LAP score
dye used in neutrophil alkaline phosphatase
diazo (alkaline pH)
poikilocyte present in myelofibrosis
dacryocytes
most aggressive form of myeloproliferative neoplasm (MPN)
myelofibrosis
- MPN with malignant hyperplasia
- high RBC but low EPO
- hyperviscosity
polycythemia vera
- clonal MPN with increased megakaryopoiesis and thrombocytosis
- giant bizarre platelets
essential thrombocythemia
group of acquired clonal hematologic disorder with progressive cytopenia + dyserythropoiesis, dysmyelopoiesis, dysmegakaryopoiesis
myelodysplastic syndrome
positive in PAS
ALL and M6
2 lymphocyte morphologic abnormality
- flame cell
- grape/mott/russel bodies
classification of acute leukemia in >30% BM blasts
FAB
classification of acute leukemia in >20% BM blasts
WHO
oncogene found in polycythemia vera and essential thrombocytopenia
JAK2 (Janus Kinase 2)
2 mature T cell lymphoma
- Mycosis fungoides
- Sezary syndrome
most common type of cutaneous lymphoma
mycosis fungoides
aggressive lymphoma with leukemic presentation and peripheral blood involvement
Sezary syndrome
excess immunoglobulins found in multiple myeloma
IgG and IgA
excess immunoglobulin found in Waldenstrom’s Macroglobulinemia
IgM
Surface markers found in plasma cells in cases of multiple myeloma
CD 38 and CD138
lymph node-based disease that have the presence of reed-sternberg cells
Hodgkin’s lymphoma
surface markers in B-cells in cases of Hodgkin’s lymphoma
CD15 and CD30
