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Hematology > WBC > Flashcards

WBC Flashcards

1
Q

leukocyte morphologic abnormality

  • hyposegmented + hyperclumped
  • “pince-nez” morphology
  • mimics leukemoid reaction (shift to left)
A

Pelger-Huet Anomaly

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2
Q

leukocyte morphologic abnormality

  • granulocytes have dark staining granules
  • due to incomplete degradation of mucopolysaccharides
  • associated with Hurler, Hunter, and Sanfilippo syndrome
A

Alder-Reilly Anomaly

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3
Q

leukocyte morphologic abnormality

  • red needles in cytoplasm
  • observed in blast cells in AML, especially APL
  • faggot cells
A

Auer Rods

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4
Q

leukocyte morphologic abnormality

disorder in the production of myosin heavy chain type IIa

A

May-Hegglin Anomaly

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5
Q

leukocyte morphologic abnormality

Triad of May-Hegglin Anomaly

A
  1. Dohle-like Bodies
  2. Thrombocytopenia
  3. Giant Platelets
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6
Q

leukocyte morphologic abnormality

  • light blue patches in cytoplasm of neutrophils
  • RNA remnants
A

Dohle bodies

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7
Q

leukocyte morphologic abnormality

immature granulocytes in peripheral blood

A

shift to the left

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8
Q

lymphocyte morphologic abnormality

lymphocytes that exhibit reactive morphology

A

downey/turk cell

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9
Q

lymphocyte morphologic abnormality

  • caused by pressure in smear prep.
  • indicates nuclear fragility
  • ⬆️ in CLL
A

basket/smudge cell

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10
Q

lymphocyte morphologic abnormality

  • plasma cell with irregular cytoplasmic projections
  • contain more immunoglobulins than normal plasma cells
  • associated with multiple myeloma
  • bright purple-red in Wright’s stain
A

Flame cell

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11
Q

lymphocyte morphologic abnormality

plasma cell with round globules
(also associated with multiple myeloma)

A

Grape/mott/rusell bodies

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12
Q

lymphocyte morphologic abnormality

lymphocyte with convoluted, cerebriform nucleus (assoc with sezary syndrome and mycoses fungoides)

A

sezary cell

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13
Q

most common type of leukemia in adults

A

acute myeloid leukemia

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14
Q

surface markers in AML

A

CD13, CD33, CD117

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15
Q

other name for FAB M4

A

Naegelli leukemia

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16
Q

other name for FAB M5

A

Schilling’s leukemia

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17
Q

other name for FAB M6

A

Di Guglielmo Syndrome

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18
Q

25-75% of childhood leukemia

A

Acute lymphoblastic leukemia

19
Q

location of genetic abnormality in ALL

A

t(12;21)

20
Q

cytochem stain for phospholipids and lipids

A

Sudan Black B

21
Q

oncogene formed from chronic myelogenous leukemia

A

BCR-ABL1

22
Q

chromosome associated from chronic myelogenous leukemia

A

Philadelphia chromosome [t(9;22)]

23
Q

diff. of CML and leukemoid reactions

A

CML has low NAP/LAP score

24
Q

dye used in neutrophil alkaline phosphatase

A

diazo (alkaline pH)

25
Q

poikilocyte present in myelofibrosis

A

dacryocytes

26
Q

most aggressive form of myeloproliferative neoplasm (MPN)

A

myelofibrosis

27
Q
  • MPN with malignant hyperplasia
  • high RBC but low EPO
  • hyperviscosity
A

polycythemia vera

28
Q
  • clonal MPN with increased megakaryopoiesis and thrombocytosis
  • giant bizarre platelets
A

essential thrombocythemia

29
Q

group of acquired clonal hematologic disorder with progressive cytopenia + dyserythropoiesis, dysmyelopoiesis, dysmegakaryopoiesis

A

myelodysplastic syndrome

30
Q

positive in PAS

A

ALL and M6

31
Q

2 lymphocyte morphologic abnormality

A
  1. flame cell
  2. grape/mott/russel bodies
32
Q

classification of acute leukemia in >30% BM blasts

A

FAB

33
Q

classification of acute leukemia in >20% BM blasts

A

WHO

34
Q

oncogene found in polycythemia vera and essential thrombocytopenia

A

JAK2 (Janus Kinase 2)

35
Q
A
35
Q

2 mature T cell lymphoma

A
  1. Mycosis fungoides
  2. Sezary syndrome
36
Q

most common type of cutaneous lymphoma

A

mycosis fungoides

37
Q

aggressive lymphoma with leukemic presentation and peripheral blood involvement

A

Sezary syndrome

38
Q

excess immunoglobulins found in multiple myeloma

A

IgG and IgA

39
Q

excess immunoglobulin found in Waldenstrom’s Macroglobulinemia

A

IgM

40
Q

Surface markers found in plasma cells in cases of multiple myeloma

A

CD 38 and CD138

41
Q

lymph node-based disease that have the presence of reed-sternberg cells

A

Hodgkin’s lymphoma

42
Q

surface markers in B-cells in cases of Hodgkin’s lymphoma

A

CD15 and CD30

Hematology (8 decks)

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