WBC Flashcards
SI unit for adult WBC
4.5 to 11 x10^9/L
Conventional unit for newborn WBC count
13,500 - 38,000 per mm^3 or uL
Most reliable criteria to determine WBC maturity
Nuclear chromatin pattern
The presence of Type 3 myeloblast is commonly associated with:
Acute myeloid leukemia
Cite the general characteristics as granulocytes mature: (5)
Chromatin condenses, nucleoli disappear, abundant basophilic cyto (nonspecific granule) becomes scanty with specific granules, nuclei indents & segment, cell size decreases
The earliest recognizable WBC granulocytic precursor
Myeloblast
This type of granulocytic precursor has azurophiic granules with more than 20. Purple cytoplasm and a dark chromatin
Type 3
Type 1 myeloblast are characterized by
Little cytoplasm (slightly basophilic), 2-4 nucleoli, no visible granule, fine nuclear chromatin
The presence of ____ in promyelocytes indicates normality of the cell
Hof
This precursor is larger than its previous precursor.
Promyelocyte
Absence of hof may indicate what disease
Acute promyelocytic leukemia
How many nucleoli may be seen in promyelocytes. Do they obscure the nucleus?
1-3
They may obscure
This precursor stage is where secondary specific granules are produced.
Myelocytic
What type of myelocyte looks similar to promyelocytes. How to distinguish it?
Early myelocyte.
It has patches of grainy pale pink cytoplasm - dawn of neutrophilia (golgi body)
Which type of myelocyte is smaller than promyelocyte? What are its other characteristic
Late myelocyte. More heterochromatin, nucleoli hard to visualize
Last stage capable of mitosis
3rd- myelocyte
This precursor must only be found in the BM among healthy individuals
Metamyelocyte
Synthesis of gelatinase granules are in this precursor stage
Metamyelocyte
Tertiary granule
Youngest precursor to normally appear in the PBS
Band cell/ stab/ staff
Secretory vesicles/ granules are formed in this stage
Band cell
How to differentiate Metamyelocyte from band cell?
Metamyelocyte - <1/2 nuclear indentation - shallow, peanut or kidney bean shape
Band celll - > 1/2 indent; sausage shape
What precursor is often mistaken as a band cell?
Metamyelocyte
Agranulocytosis has a neutrophil count of _____ commonly associated by: _____ & _____
(<0.5 x 10^9/L)
Amidopyrine and cephalosporin
Which disease/infection produces the highest EOSINOPHIL count
Trichinosis
Mod to severe eosinophilia is commonly associated with
Helminthic infection (nematode, cestode, trematode)
Most predominant type of lymphocyte
Small (7-10 um) - mostly nucleus, scanty cytoplasm
Final maturation stage of B lymphocyte
Plasma cell
Nuclear & cytoplasmic characteristic of plasma cells
Nuclear - oval, eccentric, tortoise shell, cartwheel, clock face
Cyto - dark or sea blue, cornflower color, with round discrete russel body containing Ig’s
Commonly associated disease of plasma cells
Multiple myeloma (plasma cell myeloma) - Bence Jones protein
Most abundant cell in the body
Macrophage
Functions (4) of macrophages
Phagocytose, nitric oxide (cytotoxic), IL-1 (stimulate T cell), transcobalamin 2 (primary transport vit b12)
