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3 Patho > WBC 1 > Flashcards

WBC 1 Flashcards

1
Q

Severe chronic congenital neutropenia is also known as

A

Kostmann Syndrome

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2
Q

Deficiency of this vitamin can cause ineffective granulopoesis

A

B12 (cobalamin)

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3
Q

Lack of response to an infection due to an overwhelming infection (consumption of WBC)

A

In a state of anergy WBCs are consumed in the peripheral blood to the point they are decreased.

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4
Q

Toxic granules seen in neutrophils as seen during a shift in bone marrow activity

A

Dohle bodies are formed by the activation of enzymes in the ER

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5
Q

Dohle bodies are usually seen in:

A

severe infections (sepsis), or severe inflammatory reactions (Kawasaki’s)

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6
Q

Agranular, enlarged lymphocytes as a result of antigen stimulation (normal N/C ratio)

A

Reactive lymphocytes

Or Atypical lymphocytes

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7
Q

The presence of what cells may indicate neoplastic proliferation?

A

blasts

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8
Q

Defined by the presence of large oblong germinal centers surrounded by a collar of small resting naive B cells

A

Follicular hyperplasia

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9
Q

Hyperplasia of cells lining the lymphatic sinusoids where HISTIOCYTE (tissue macrophage) number is greatly increased

A

Sinus histiocytosis.

(Active B cells in center
Inactive B cells in periphery)

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10
Q

Pattern of chronic lymphadenitis usually caused by drugs, IM, vaccines

A

Parafollicular hyperplasia

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11
Q

Follicular hyperplasia is the stimulation of which compartment?

A

B-cell (compartment of lymph nodes)

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12
Q

Dark zone of germinal region contain these proliferating B cells

A

Centroblasts

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13
Q

Abnormal expansion of the interfollicular zones but is confined within the lymph node capsule

A

Parafollicular hyperplasia

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14
Q

Marginal layer gets thinner; germinal center gets larger.

A

Follicular hyperplasia

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15
Q

Lymph node hyperplasia prominent in breast carcinoma

A

Sinus hyperplasia

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16
Q

Foreign bodies are attacked by killer T cells here

A

parafollicular

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17
Q

Folluclar hyperplasia is a chronic reaction that can be seen in these infections: (examples)

A

HIV, toxoplasmosis

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18
Q

Light zone of germinal centers contain these B cells with irregular or cleaved nuclear contours

A

Centrocytes

Some will be come memory cells

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19
Q

Macrophages that eat up failed B cells that have undergone apoptosis are called:

A

tingible bodies

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20
Q

Lymphoid neoplastic proliferation arising as discrete tissue masses in LYMPH NODES

A

lymphoma

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21
Q

Type of myeloid neoplasm: immature progenitor cells accumulate in the BM

A

Acute myeloid leukemia

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22
Q

Increased WBC count with left shift (80% bands)

increased leukocyte alkaline phosphatase

A

Leukemoid reaction

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23
Q

Reed-Sternberg cells (RS cells) are required for diagnosis of:

A

Hodgkin’s lymphoma

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24
Q

Neoplasms that present with widespread involvement of the bone marrow and peripheral blood; arise in BONE MARROW

A

Lymphocytic leukemia

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25
Q

Type of myeloid neoplasm: associated with ineffective hematopoiesis and resultant peripheral blood cytopenias

A

Myelodysplastic syndrome

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26
Q

WHO class of lymphoma which includes:
adult T cell lymphoma (ATL)
Anaplastic large cell lymphoma (ALCL)
Sezary’s and Mycosis fungoides

A

Peripheral T cell lymphoma (MATURE T cell)

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27
Q

Clover leaf or flower cells in PBS

A

Adult T-cell lymphoma

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28
Q

Type of myeloid neoplasm: increased production of one or more terminally differentiated myeloid elements which usually leads to elevated peripheral blood counts

A

Chronic myeloproliferative disorder

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29
Q

Distinct tumor giant cell. Binucleate, mirror imaged. Owl eyes.

A

Reed-Sternberg cells induce the accumulation of other inflammatory cells

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30
Q

WHO class of lymphoma which includes B lymphoblastic leukemia (ALL) / lymphoma

A

Precursor B cell (Neoplasm of IMMATURE B cell)

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31
Q

Sezary’s and Mycosis fungoides manifest what lesions?

A

Skin lesions (T cells tend to go to skin)

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32
Q

WHO class of lymphoma which includes hairy cell leukemia, Burkitt’s and Follicular Lymphoma.

A

Peripheral B cell CLL, SLL (Neoplasm of MATURE B cell)

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33
Q

Leukocyte common antigen

A

CD45

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34
Q

T cell antigen

A

CD5
CD4 / CD8
CD3

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35
Q

B cell antigen

A

CD10
CD19

CD20 (pre B, mature B)
IgM

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36
Q

Monocyte antigen

A

CD14

CD64

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37
Q

Stem cell antigen

A

CD34

38
Q

Hodgkin antigen

A

CD15, CD30

39
Q

Peripheral T cell antigen

A

CD3

40
Q

Pan-B marker

A

CD19

41
Q

Ratio of kappa light chain B cells to lambda light chain B cells (benign)

A

2:1

2/3 are kappa
1/3 are lambda

(When one light chain is significantly more common than the other, it suggests derivation from a monoclonal population indicating MALIGNANCY)

42
Q

Small, painful, solitary lymphatic enlargements indicate:

A

Benign

lymphoma presents as multiple and painless

43
Q

A nodular white lymph node specimen when cut probably indicates:

A

lymphoma

44
Q

Bcl-6 (30%)

t(14:18) (10%)

A

DLBCL

also bcl-2

45
Q

Starry-sky appearance on PBS

A

Burkitt’s lymphoma

46
Q

Neoplasm that presents in children <15 years

A

Acute Lymphoblastic Lymphoma/Leukemia

47
Q

Caused by HTLV-1

A

Adult T cell lymphoma

48
Q

Marker of pre-T and pre-B cells

A

TdT+

Terminal Dioxynucleotidil Transferase

49
Q

(+) TdT, (+) CD5

A

T-ALL

pre-T cell lymphoma

50
Q

Peaks at 4 years old

A

pre-B ALL

At 4 years old B cells are maximal in bone marrow

51
Q

(+) CD15 could indicate

A

Hodgkin’s lymphoma

52
Q

(+) CD5, (+) CD23
vs
(+) CD5, (-) CD23

A

SLL
vs
Mantle cell lymphoma

53
Q

Pre-T ALL usually has this clinical manifestation

A

mediastinal mass

Rapidly fatal if left untreated. Good remission with treatment.

54
Q

Follicular lymphoma progression to DLBCL because of this gene rearrangement or mutation

A

c-MYC

55
Q

c-myc activation

A

Burkitt’s

56
Q

(+) TdT, (+) CD19

A

Pre-B cell lymphoma

57
Q

Jaw lesion of Burkitt’s lymphoma is:

A

endemic form

58
Q

bcl-2 expression seen in which lymphoma?

A

Follicular lymphoma

can be seen in DLBCL

59
Q

Difference between SLL and CLL

A

CLL has increased peripheral blood WBC

CLL is a stage of SLL

60
Q

t(11;14)

A

Translocation of 11 and 14
cyclin D1 upregulation –> promotion of G1 to S

Mantle Cell Lymphoma

61
Q

t(8;14)

A

translocation

c-myc activation (inactivates p53)

62
Q

Affects male:female::2:1, >60 y/o, and often asymptomatic.

A

SLL/CLL

63
Q

Cyclin D-IgH function?

Associated with what type of lymphoma?

A

Promotes G1 to S

Mantle Cell Lymphoma

64
Q

ALK positivity is typical but not required in

A

Anaplastic large cell lymphoma

65
Q

EBV

A

Burkitt’s Lymphoma

EBV stimulatesNF-kappa B

66
Q

t(9;22)

A

Translocation of 9 and 22

CML (Philadelphia chromosome)

67
Q

In the indolent course, this lymphoma is incurable

A

Follicular lymphoma

68
Q

NHL with BIPHASIC prevalence: elderly and pediatric

A

DLBCL

69
Q

Sporadic form of this neoplasm affects the pelvis or abdomen

A

Burkitt’s lymphoma

70
Q

t(14;18)

A 
Translocation
Follicular Lymphoma (bcl-2 activation inhibits apoptosis)
71
Q

Progression (complication) where lymphoma transforms into DLBCL

A

Richter Syndrome

from HCL, CLL/SLL

72
Q

Trisomy 12

A

CLL/SLL

73
Q

Clinical manifestation of Extranodal NK/T cell Lymphoma

A

nasal: nasopharanx, oropharynx, nose, oral cavity

Cutaneous like Sezary and Mycosis fungoides

74
Q

Lymphoma associated with warm IHA/AIHA

A

CLL/SLL

75
Q

This has 3 Clinical stages: inflammatory, plaque, tumor

A

Mycosis fungoides

76
Q

Skin lesions + hypercalcemia

A

Adult T-cell lymphoma

77
Q

CNS + testicular involvement is a manifestation of:

A

ALL

78
Q

Hallmark cell is horseshoe-shaped nuclei

A

Anaplastic large cell lymphoma

79
Q

Smudge cells in PBS

A

CLL/SLL

80
Q

WHO class of lymphoma which includes T lymphoblastic Leukemia/Lymphoma

A

Precursor T cell (neoplasm of IMMATURE T cell)

81
Q

Clinical feature of this HL: mediastinal or cervical mass

A

Nodular sclerosis HL

82
Q

Non-classical Hodgkin’s Lymphoma subtype

A

Lymphocyte predominant HL has (-) CD15 and (-) CD30

83
Q

Hodgkin lymphoma subtype with presence of frequent mononuclear variants and RS cells with CLASSICAL IMMUNOPHENOTYPIC profile

A

Lymphocyte rich HL

in Lymphocyte predominant HL, classical RS cells are difficult to find

84
Q

Hodgkin’s lymphoma associated with HIV+

A

Lymphocyte depletion HL

85
Q

Most common HL

A

Nodular sclerosing HL

86
Q

Histological feature of this HL: Frequent RS cells surrounded by reactive cells (eosinophils, lymphocytes, histiocytes)

A

Mixed-cellularity HL

87
Q

Histology of this HL reveals collagen banding and lacunar cells

A

Nodular sclerosing HL

88
Q

Popcorn cell =

A

Lymphocyte predominant HL

multilobed nucleus

89
Q

These two subtypes of Hodgkin’s lymphoma are usually not associated with EBV

A

Nodular sclerosing
and
Lymphocyte predominant

90
Q

Classic HL that is commonly (-) for EBV

A

Nodular sclerosing HL

91
Q

HL with poorest prognosis

A

Lymphocyte depletion HL

3 Patho (8 decks)

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