Watts Flashcards
Name the 5 steps in the HIV entry
1) GP120 +CD4 binding
2) conformational change
3) GP120 + CD4 bind CCR5
4) GP41 membrane penetration
5) membrane fusion
Name two co-receptors that could be involved in the HIV cell cycle
CCR-5
CXCR4
Mutations in what receptors can cause resistance to HIV
CCR5 mutations
In HIV treatment what does NRTIs stand for
Nucleoside/nucleotide reverse transcriptase inhibitors
Name 6 types of anti-viral approved for treatment of HIV
1) NRTI
2) NNRTI
3) protease inhibitors
4) fusion inhibitors
5) integrase inhibitors
6) CCR5 antagonists
How do NRTIs work
Act as chain terminators or inhibitors at the substrate binding site of RT
How do NNRTIs work
Inhibit viral DNA by binding at the allosteric non-bonding site of RT causing a conformational change of the active site
During the reproduction cycle of HIV a specific protease is required to process what two polyproteins into mature HIV components
GAG
POL
All approved protease inhibitors contain what bond instead of a normal peptide bond
Hydroxyethylene bond
Name a fusion inhihitor used in HIV
Fuzeon
What is fuzeon and how does it work
36 aa rationally designed fusion inhibitor- mimics components of GP41 preventing normal fusion
What is raltegravir
Integrase inhihitor in HIV treatment
Name a CCR5 inhihitor (entry inhibitor)
Maraviroc
What does HAART stand for
Highly active anti-retro viral therapy
What are two benefits of HAART
Reduces incidence of resistance
Can reduce toxicity/side effects by lowering dose
