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Infection&immunity > D Taylor, blag and Nick had- fungal > Flashcards

D Taylor, blag and Nick had- fungal Flashcards

1
Q

Fungi are divided into what two classes

A

Yeasts

Moulds

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2
Q

True/ false - yeasts are multicellular and also known as filamentous fungi

A

False this is Moulds

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3
Q

True/false yeasts reproduce by budding or fission

A

True

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4
Q

Fungi are carbon heterotrophs, therefore they require what?

A

Organic compounds as carbon sources

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5
Q

What age can you use terbinafine for ringworm treatment

A

Over 12s only

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6
Q

Griseofulvin is effective against what species

A

Microsporum sp

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7
Q

Terbinafine is effective against what species

A

Trichophyton tonsurans

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8
Q

Do you take griseofulvin with fatty foods

A

Yes to help absorption

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9
Q

Are fungi pro or eukaryotic organisms

A

Eukaryotic - they have a true nucleus

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10
Q

Define severe sepsis

A

Sepia plus sepsis induced organ dysfunction/tissue hypo-perfusion

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11
Q

Define septic shock

A

Sepsis induced hypotension persisting despite adequate fluid resuscitation

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12
Q

Name 4 main causative species of invasive fungal infections

A

Candida
Aspergillus
Cryptococcus
Histoplasma capsulatum

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13
Q

True/false aspergillus is a yeast

A

FALSE ITS A MOULD DUH

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14
Q

Aspergillus is a common environmental pathogen therefore tends to cause what kind of infections

A

Pulmonary infections

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15
Q

Name two types of aspergillus infections

A

Aspergillosis

Aspergilloma

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16
Q

What type of fungi is cryptococcus

A

YEAST

17
Q

What is beta-D-glucan

A

Cell wall component of fungi detected in blood

18
Q

What is galactomannan

A

Surface component of fungi - used to detect for diagnosis

19
Q

Can antifungals be toxic to us?

A

Yeh cos fungi are eukaryotes so more similar to our own cells than e.g bacteria

20
Q

Name 4 classes of antifungals

A

Azoles
Echinocandins
Polyenes
Nucleoside analogues

21
Q

How do Azoles work

A

Inhibition of ergosterol biosynthesis in the cell membrane

22
Q

How do echinocandins work

A

Inhibition of beta-1,3-glucan synthesis in the cell wall

23
Q

How do polyenes work

A

Ergosterol disruption in cell membrane

24
Q

What’s the mechanism of action of triazoles

A

Decreased ergosterol production through inhibition of fungal CYP450 enzymes

25
Q

How does the polyene amphoterocin work

A

Binds to ergosterol in fungal cell membrane, creates pores, increasing permeability

26
Q

What is CaMdr1p?

A

A major facilitator superfamily (MFS) antifungal efflux transporter protein of Candida albicans

27
Q

The unique and conserved antiporter motif on CaMdr1p is called what

A

Motif C

28
Q

What are Cdr1p and Cdr2p

A

Multi drug transporters of candida in the ABC superfamily

Infection&immunity (9 decks)

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