D Taylor, blag and Nick had- fungal Flashcards
Fungi are divided into what two classes
Yeasts
Moulds
True/ false - yeasts are multicellular and also known as filamentous fungi
False this is Moulds
True/false yeasts reproduce by budding or fission
True
Fungi are carbon heterotrophs, therefore they require what?
Organic compounds as carbon sources
What age can you use terbinafine for ringworm treatment
Over 12s only
Griseofulvin is effective against what species
Microsporum sp
Terbinafine is effective against what species
Trichophyton tonsurans
Do you take griseofulvin with fatty foods
Yes to help absorption
Are fungi pro or eukaryotic organisms
Eukaryotic - they have a true nucleus
Define severe sepsis
Sepia plus sepsis induced organ dysfunction/tissue hypo-perfusion
Define septic shock
Sepsis induced hypotension persisting despite adequate fluid resuscitation
Name 4 main causative species of invasive fungal infections
Candida
Aspergillus
Cryptococcus
Histoplasma capsulatum
True/false aspergillus is a yeast
FALSE ITS A MOULD DUH
Aspergillus is a common environmental pathogen therefore tends to cause what kind of infections
Pulmonary infections
Name two types of aspergillus infections
Aspergillosis
Aspergilloma
What type of fungi is cryptococcus
YEAST
What is beta-D-glucan
Cell wall component of fungi detected in blood
What is galactomannan
Surface component of fungi - used to detect for diagnosis
Can antifungals be toxic to us?
Yeh cos fungi are eukaryotes so more similar to our own cells than e.g bacteria
Name 4 classes of antifungals
Azoles
Echinocandins
Polyenes
Nucleoside analogues
How do Azoles work
Inhibition of ergosterol biosynthesis in the cell membrane
How do echinocandins work
Inhibition of beta-1,3-glucan synthesis in the cell wall
How do polyenes work
Ergosterol disruption in cell membrane
What’s the mechanism of action of triazoles
Decreased ergosterol production through inhibition of fungal CYP450 enzymes
