Water soluble vitamins - Thiamin (B1)

Question 1

What are the functions for each form of thiamin

Answer 1

TTP - noncoenzyme - nervous system - regulates sodium channels and chloride transport in nerve transduction

TDP or TPP - coenzyme - energy production by DEHYDROGENASES (pyruvate to acetylCoa) - NADPH and pentose synthesis - part of TRANSKETOLASE

Question 2

what is a thiamin deficiency and what are different variations

Answer 2

major targets = peripheral nerves, heart, and brain

chronic thiamin deficiency = beriberi (in diets where most of diet is polished rice)

Question 3

what is wernicke-korsakoff syndrome

Answer 3

chronic thiamin deficiency in alcoholics

• dec thiamin intake, absorption, utilization
• psychosis, delirium, ataxia, vomit, large heart
• thiamin is MC NUTRITIONAL DEFICIENCY IN ALCOHOLICS (yikes)

Question 4

what are sources of thiamin

Answer 4

yeast, pork, whole grains, enriched grains, legumes

Question 5

what are poor sources of thiamin

Answer 5

raw fish and shellfish

Question 6

dry beriberi

Answer 6

low thiamin high carb

muscle weak, extremity wasting, peripheral neuropathy, tender calves

Question 7

wet beriberi

Answer 7

enlarged heart, rapid heart beat, peripheral EDEMA, high blood pressure

Question 8

acute beriberi

Answer 8

chronic infant deficiency (2-5 months of age)
breastfed by mothers with poor thiamin intake
anorexia, nausea, vomiting, lactic acidosis