Water soluble vitamins - Niacin (B3)

Question 1

What are functions of Nad and NADPH

Answer 1

mostly dehydrogenases
H acceptors in redox
NAD - glycolysis, krebs, beta oxidation, ethanol metabolism
NADPH - fatty acid synthesis, cholesterol synthesis, folate synthesis

Question 2

what enzymes use B1, B2 and B3

Answer 2

dehydrogenases

Question 3

which step in beta oxidation uses niacin

Answer 3

2nd step

2nd O in OHOT (1st O was riboflavin)

Question 4

what is niacin made from?

Answer 4

tryptophan

Question 5

what are the coenzymes and cofactors for this process

Answer 5

iron, riboflavin, vitamin B6

Question 6

what are dietary sources

Answer 6

enriched cereals, chicken, fish, pork, beef, peanuts, yeast

Question 7

what are the 4Ds of pellagra

Answer 7

Dermatitis
Dementia
Diarrhea (includes inflammation of mucus membrane of mouth and GI tract)
Death

Question 8

diets in high what foods are more likely to cause pellagra

Answer 8

corn

Question 9

what deficiency is often found with pellagra

Answer 9

ariboflavinosis (riboflavin deficiency)

both have cheilosis, angular stomatitis, glossitis

Question 10

what are side effects of niacin toxicity

Answer 10

no evidence from dietary sources

-vasodilation (flushing from histamine), heartburn, liver damage, gout, impaired blood glucose