water soluble vitamins - biotin (B7) Flashcards
1
Q
what enzymes need biotin
A
CARBOXYLASES
-pyruvate carboxylase - pyruvate to oxaloacetate -
replenish oxaloacetate for TCA and gluconeogenesis
-acetylCoA carboxylase- acetylCoA to malonylCoA - committed step in FA synthesis
2
Q
what are other functions of biotin
A
noncoenzyme roles - transcription of several enzymes
(glucokinase, phosphoenol pyruvate carboxykinase)
3
Q
what are sources of biotin
A
bacteria in LI, peanuts, almonds, soy, eggs, dairy, sweet potatoes
4
Q
what is avidin
A
in raw egg whites and is a biotin chelator - will bind and prevent absorption
5
Q
what are signs/symptoms of a biotin defiency
A
dermatitis, anorexia, depression, alopecia, muscle pain, lethargy, halllucinations
