Water-Soluble Vitamins Flashcards

1
Q

sources of vit C

A

citrus

peppers

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2
Q

functions of vit C

A

antioxidant
non-heme absorption
collagen synthesis

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3
Q

step in collagen synthesis that vit C is important for

A

hydroxylation

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4
Q

deficiency of vit C is called

A

scurvy

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5
Q

toxicity of vit C is

A

diarrhea

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6
Q

4 H’s of scurvy

A

hemorrhagic signs
hyperkeratosis of hair follicles
hypochondriasis
hematologic

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7
Q

B1 is named

A

thiamin

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8
Q

coenzyme form of B1

A

TDP

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9
Q

noncoenzyme form of B1

A

TTP

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10
Q

TDP is used in which step in kreb’s cycle

A

pyruvate –> Acetyl CoA

transketolase

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11
Q

TTP regulates:

A

Na+/Cl- transport

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12
Q

sources of thiamin

A

pork

whole grain

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13
Q

deficiency of _____ is called _____ is common in ALCOHOLICS

A

B1/thiamin

wernicke-korsakoff

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14
Q

beriberi is a deficiency of

A

B1/thiamin

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15
Q

symptoms of WET beriberi

A

tender calf muscles
adults
enlarged heart
peripheral neuropathy

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16
Q

type of Beriberi in geriatrics

A

dry

peripheral neuropathy

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17
Q

symptoms of ACUTE beriberi

A

babies
enlarged heart
(only one WITHOUT peripheral neuropathy)

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18
Q

B2 is called

A

riboflavin

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19
Q

coenzymes of riboflavin

A

FAD & FMN

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20
Q

riboflavin (FAD/FMN) is coenzyme for

A

dehydrogenase

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21
Q

riboflavin is needed for which reactions

A

ETS
krebs
beta-oxidation – STEP 1

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22
Q

riboflavin important for synthesis of (2)

A

niacin

B6

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23
Q

sources of riboflavin

A

green leafy veggies
dairy
whole grains

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24
Q

riboflavin deficiency is called

A

ariboflavinosis

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25
Q

two forms of ariboflavinosis

A

mouth

dermatitis

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26
Q

types of ariboflavinosis

A

cheilosis
glossitis
angular stomatitis
magenta tongue

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27
Q

Niacin is AKA

A

B3

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28
Q

Niacin is made from

A

tryptophan

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29
Q

function of niacin w/ coenzyme NAD

A

dehydrogenase

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30
Q

step in beta oxidation that niacin is used for

A

step #2

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31
Q

function of niacin w/ coenzyme NADPH

A

synthesis of FA & triglyceride

32
Q

best source of niacin

A

meat

33
Q

deficiency of B3/niacin is called

A

pellagra

34
Q

symptoms associated with pellagra

A
dermatitis
diarrhea
dementia
death
(4 D's)
35
Q

toxicity of niacin/B3

A

liver damage

flushing

36
Q

B6 is called

A

pyridoxine

37
Q

sources of B6

A

meat***

whole grains

38
Q

2 deficiencies found together

A

pellagra

ariboflavinosis

39
Q

coenzyme for B6

A

PLP (pyridoxal phosphate)

40
Q

function of B6 and PLP

A

AA metabolism

41
Q

PLP and B6 are necessary for (3)

A

heme
neurotransmitters
myelin sheath

42
Q

toxicity of B6 can lead to

A

peripheral neuropathy* (associated with both toxicity and deficiency*)

43
Q

symptoms of B6 deficiency (2)

A

fatigue

peripheral neuropathy**

44
Q

deficiency of B6 has same mouth symptoms as ___, except ___

A

B2- riboflavin
(glossitis, cheilosis, stomatitis)
magenta tongue

45
Q

B5 is aka

A

pantothenic acid

46
Q

deficiency of B5

A

burning feet

47
Q

sources of B5

A

meat
legumes
whole grains

48
Q

B5 is a part of ____ in Kreb’s cycle & beta oxidation and ____ in lipid synthesis

A

CoA

acyl-carrier protein (ACP)

49
Q

B7 is aka

A

biotin

50
Q

B7 is bound to

A

carboxylase

51
Q

sources of biotin

A

LI bacteria
dairy
nuts

52
Q

3 symptoms of deficiency of B7

A

dermatitis
glossitis
increase LDL (bad cholesterol)

53
Q

B7 deficiency is most likely found in which category of people

A

pregnant

54
Q

avidin in _____ is a BIOTIN _____ and will bind and prevent absorption

A

raw eggs

chelator

55
Q

natural form of B9

A

folate

56
Q

synthetic form of B9

A

folic acid

57
Q

sources of folate

A

dark green leafy veggies

legumes

58
Q

sources of folic acid

A

supplements

fortified cereals

59
Q

function of B9 is for ____ leading to synthesis of (3)

A

THF (tetrahydrofolate)
DNA
RBC
WBC

60
Q

folate requires _____ for absorption of ____ ; which is inhibited by legumes, oranges, cabbage

A

conjugase

zinc

61
Q

folic acid ____ ZINC absorption

A

decreases zinc

62
Q

folate deficiencies (2)

A

neural tube defects

megaloblastic anemia

63
Q

B12 is aka

A

cobalamin

64
Q

coenzyme form of B12 that’s function is AA metabolism

A

adenosylcobalamin

65
Q

coenzyme form of B12 that’s function is MYELINATION and removal of homocysteine

A

methylcobalamin

66
Q

best sources of B12

A

meat
fish
diary

67
Q

2 deficiencies of B12

A

megaloblastic anemia

pernicious anemia

68
Q

impaired _____ from ____ cells of stomach leads to _____ anemia

A

intrinsic factor
parietal cells
pernicious

69
Q

cobalamin is stored in

A

liver

70
Q

b12 is transported via

A

transcobalamin

71
Q

cobalamin is absorbed by

A

receptor mediated endocytosis

72
Q

cobalamin is digested by

A

proteases

73
Q

cobalamin binds in STOMACH by _____ from ____

A

R protein

saliva

74
Q

cobalamin binds in SI by ____ from ____ cells in STOMACH

A

intrinsic factor

parietal cells

75
Q

impaired intrinsic factor secretion in patients with: (2)

A

zellinger-ellison syndrome

reflux syndrome

76
Q

decreased receptor mediated endocytosis is in patients with (2)

A

malabsorption

pancreatic insufficiency