W5 Flashcards
who was the leader in the definition of SCD?
Dr. Frank Jessen
what is SCD?
self-experience or awareness of own decline
personal observation, impression, and/or belief that one is declining cognitively
when does SCD become valid?
in later ages but can occur at any point
what was the result from the Mitchell study?
cognitively normal people with subjective complaints were 2x as likely to develop dementia than those without complaints
is SCD an important consideration in preclinical AD?
yes
what is the problem with defining SCD?
many diff terms
- subjective perceptions of decline often fade - inconsistency
what is a questionable etiology from SCD?
is it a by-product of aging-related worry, health conditions, anxiety, stereotypes?
how do you measure SCD?
no single accepted approach
- tap into ability/disability, change/decline
what did Jessen use to measure SCD?
complaints
concerns
what are the top 3 biggest changes?
memory
executive
attention
what are the research criteria for SCD?
- self-experienced persistent decline in cog capacity in comparison with normal status and unrelated to an acute event
- normal age-, gender-, and education-adjusted performance on standardized cog tests used to classify MCI or prodromal AD
what are the exclusion criteria for SCD?
- mild cognitive impairment, prodromal AD or dementia
- can be explained by psychiatric or neurologic disease, medical disorder, meds, substance use
what is the name of the assessment used to detect MCI?
MOCA
- Montreal Cognitive Assessment
what are the RF/PF and biomarkers of SCD?
age
education
APOE genetic risk
beta-amyloid burden
frailty
sex
what were the key results from the multifaceted SMD study 1?
- episodic memory trajectories were predicted by facet and sex
- more memory complaints and memory concerns/anxiety predictive of change in memory in F. not M
- more memory self-efficacy is predictive of change in memory in males but not females
