W1

Question 1

what kind of decline do aging-related trajectories show?

Answer 1

modest and gradual

Question 2

at what age does normal to gradual decline usually start at?

Answer 2

30-40

Question 3

at what age does significant impairment levels and rapid decline to dementia start at?

Answer 3

40-50

Question 4

AD

Answer 4

Alzheimer’s disease

Question 5

ADRD

Answer 5

AD and Related Disorders

Question 6

NDD

Answer 6

Neurodegenerative disease

Question 7

NA

Answer 7

normal aging

Question 8

MCI

Answer 8

mild cog impairment

Question 9

BCA/BCAD

Answer 9

brain, cog, aging, dementia

Question 10

NIH

Answer 10

US National Institutes of Health

Question 11

CIHR

Answer 11

Canadian Institutes of Health Research

Question 12

CCNA

Answer 12

Canadia Consortium on Neurodegeneration in Aging

Question 13

ASC

Answer 13

Alzheimer Society of Canada

Question 14

what are the 4 transitional “phenotypes” of BCA?

Answer 14

• healthy/exceptional brain/cog aging
• normal/typical brain/cog aging
• impaired/preclinical brain/cog aging
• diagnosed NDD and Dementia

Question 15

how many years prior to diagnosis can NDD start?

Answer 15

5-10 yrs

Question 16

what is the purpose of risk factors?

Answer 16

support trajectories direction

Question 17

what is the trajectory and outcome for normal unimpaired BCA?

Answer 17

• NA and CU
• maintenance and typical decline

Question 18

what is the trajectory and outcome for MCI?

Answer 18

• at-risk state
• potential transitional to NDD

Question 19

what is the trajectory and outcome of NDD?

Answer 19

• AD and Demntia

Question 20

which group is exceptional brain grouped with?

Answer 20

normal cog aging - just diff phenotype

Question 21

what is the trajectory and outcome of exceptional brain and cog aging?

Answer 21

sustained lvls into late life

Question 22

what is the avg age of decline?

Answer 22

75

Question 23

what was the groundbreaking lecture?

Answer 23

1906
- Dr. Alois Alzheimer identified “unusual disease of cerebral cortex”
-> identified in 55 yr old woman who died

Question 24

what did Dr. Alz discover in the tissue?

Answer 24

many globs of sticky proteins in spaces b/w neurons and tangled bundle of fibrils within neurons
- beta-amyloid plaques
- neurofibrillary tangles

Question 25

what was the hallmark of AD?

Answer 25

plaques and tangles

Question 26

who was Frau August D?

Answer 26

51 yr old lady with serious memory problems, sus behavior (thought ppl were conspiring against her), language problems

Question 27

what was the trajectory for Frau Auguste D?

Answer 27

rapid degeneration of all symptoms spreading decline across other domains bedridden

Question 28

ich habe mich verloren

Answer 28

i have lost myself - identity and memory

Question 29

what did Frau's autopsy show?

Answer 29

AD observed - dramatic shrinkage in cerebral cortex - abnormal deposits in and around cells - fatty deposits in small blood cells

Question 30

risk factor

Answer 30

increases risk of disease/condition

Question 31

protection factor

Answer 31

decreases risk of disease/condition

Question 32

incidence

Answer 32

number/rate of disease in time frame

Question 33

prevalence

Answer 33

total number of cases at specified time - larger than incidence

Question 34

what was Dr.Goldman's rationale?

Answer 34

dementia is the greatest health challenge of Canada's aging. we don't know the scale of the challenge and the impact on Canadians

Question 35

how many Canadians have dementia?

Answer 35

600,000

Question 36

what are the 5 main goals of the Landmark study?

Answer 36

- clarify the path forward: update public knowledge and how we expect numbers to change over next 30 yrs - improve knowledge: break down complexity and highlight key areas of risk reduction - advocate: many ppl support ppl w dementia and provide formal and informal care - create action: inspire many type of ppl including gov't to support and work towards programs and policies to promote better brain health - push for change: need for action -> funding, changes, reduce stigma and stereotypes and implement solutions

Question 37

how many ppl each day in 2022 were diagnosed with dementia?

Answer 37

over 350

Question 38

how many hours per week does someone spend taking take of a person with dementia?

Answer 38

26 hours a week

Question 39

what are the key gaps needed to be addressed?

Answer 39

- incomplete understanding of risk and protective factors - home care and long-term care sys -> under strain and facing crises, need a remodel of care sys - the challenges associated with providing care (financial, burnout, depression, isolation)

Question 40

how many cases between 2020-2049?

Answer 40

6,328.200

Question 41

what is the major risk factor for dementia?

Answer 41

age

Question 42

who is more likely to get dementia?

Answer 42

F

Question 43

what 4 provinces have the highest number of cases?

Answer 43

ontario quebec bc ab -> fastest growing provinces

Question 44

t or f: the project prevalence and incidence for AB citizens is consistent

Answer 44

t

Question 45

what is Alz Association motto?

Answer 45

our vision is a world without Alz disease

Question 46

what is the 6th leading cause of death?

Answer 46

Alz

Question 47

how much could ADRD cost by 2050?

Answer 47

1.1 trillion

Question 48

how many Americans will have AD by 2050?

Answer 48

14 M

Question 49

what did Dr.Khachaturian do?

Answer 49

discovered a crucial historical link in emergence of AD public awareness, scientific research and intervention efforts