W4 - Introduction to muscle and the lower limb Flashcards
What parts consitute the muscle-tendon unit (MTU)?
The muscle belly and tendon, that transmit force to the skeleton
What is the heirarchical strucutre of muscle?
- Muscle
- Fibre bundle
- Fascicle
- Fibre (cell)
- Myofibrils
- Filament
- Sarcomere
What are the three types of fascia fount in muscle?
- Epimysium
- Perimysium
- Endomysium
Which type of fascia surrounds a fibre bundle?
Epimysium
Which type of fascia surrounds a fascicle?
Perimysium
What type of fascia seprates muscle fibres (cells)?
Endomysium
What is the cell membrane of a muscle fibre (cell) called?
Sarcolemma
Describe the microscopic organisation of a muscle fibre
- Many nuclei
- Sarcoplasm - cytoplasm of the musclular cell, contataining glycogen and other fuels
- Mitochondria for cell metabolism
- Myofibril - contractile apparatus
- Membranous system - Sarcoplasmic retiulum and T tubule
What does the myofibril consist of?
Many sarcomeres
What is a sarcomere?
The contractile machinery of muscle
What is the Z line?
Stucture of the sarcomere
The point at which the thin actin fillaments join.
Found in the centre of the I band.
What is the I band?
Stucture of the sarcomere
The space not occuiped by the thick myosin fillament
What is the M line?
Stucture of the sarcomere
The point “line” the thick myosin fillaments connect. Positioned in the centre of A band/ H zone
What is the A band?
Stucture of the sarcomere
The space occupied by the thick myosin fillaments
What is the H zone?
The are not occupied by the thin actin fillament, it is occupied by the thick myosin fillament. Same area as M line. Central of A band.
What area is the sarcomere?
The sarcomere spans the area between both Z lines
Summarise the mechanism of contraction in the sliding fillament theory
- Action potential travels along the sarcolemma
- Action potential enters the cell at Transverse Tubule (TT) and triggers release of calcium into the cell
- Calcium binds to topomyosin, tropomyosin “unblocks” the actin fillaments
- Myosin heads bind with actin to form cross bridges and complete the power stroke - actin and myosin move closer together
- ATP fuels the pumping back of calcium into the SR which “re-sets” the system
How does the amount of force developed in a muscle relate to the number of cross bridges formed?
The amount of force developed in a muscle is directly propeortional to the number of cross bridges formed
How do sarcomeres want to change in length?
Sarcomeres always want to shorten - the external force dictates changes in muscle (or MTU) length
Describe the sliding fillament mechanic and the power stroke
- Lever movement of myosin head drive displacement of actin relative to myosin
- This also deforms internal elastic structures, developing force (~5 pN)
- Thick and thin fillaments “slide” relative to each other
What is the maximal force a muscle can generate?
40N cm2
How is muscle organised?
Hierarchically, allowing the mechanism of contraction when an action potential reaches the muscle