W3L2 Acute Hepatitis

Question 1

Def

Answer 1

Acute inflammation of liver result from wide range etiologies

Question 2

Hepis A inf

Answer 2

1. Transmission(fecal-oral)
2. Incubation period(4w)
3. Excrete in stool(7-14d) after onset clinical illness & diagnostic acute HAV inf
4. No carrier state
5. Inactivate attenuate vac( safe, immunogenic & effective)

Question 3

CP HepA

Answer 3

• Incubation period(15-45d)
• Prodromal sym systemic(low grade fever, anorexia, nausea, vomiting)
• Fatigue, malaise, arthralgias, myalgias, headache, pharyngitis, cough
• Dark urine & clay color stool(1-5d b4 onset)
• Liver enlarged & tender & asso w ruq pain & discomfort

Question 4

Lab diag

Answer 4

• Acu hepis w cli jaundice(s bili lvl >2.5mg/dL & s ALT >10x)
• IgM ab detectable 5-10d b4 onset sym & up to 6mon Anti-HAV IgM ab=acu inf

Question 5

Management HAV

Answer 5

• Xfx antiviral drugs
• Recover completely
• Fatality (~0.1%) but inc advance age & presence underlying debilitating dis