W3L1 Liver Fx Test

Question 1

Class

Answer 1

A) Test liver capacity to transport organic anions & metabolize drug (S bilirubin, urine bilirubin, urobilinogen)

B) Test detect injury to hepatocytes (s enzyme test)– Aminotransferase

C) Test Liver’s biosynthetic capacity- S proteins, albumin, PTT

Question 2

various uses of Liver function test

Answer 2

• Screening- liver dysfx
• Pattern dis- dif acute viral hepatitis, various cholestatic disorders, chronic liver disease
• Assess severity- & predict dis(1ry biliary cirrhosis)
• Follow up- response therapy(autoimmune hepatitis)

Question 3

Aminotransferase

Answer 3

1. <=300 IU/ml
   - alcoholic hepais, chro viral hepais
2. 500-5k IU/ml
   - acu vir hepais, drug reaction
3. > 5k IU/ml
   - ischemia, herpes simplex hepais
4. AST:ALT
   - >2(alco liver dis)
   - AST > in cirrhotic pt

Question 4

Cholestasis

Answer 4

Impair bile flow

Question 5

CP Jaundice

Answer 5

• Infant(major)
• Adolescene(acu vir hepis)
• Young adult(vir hepis)
• Elderly(>50% liver malig)

Question 6

Total bilirubin

Answer 6

TB= Unconju(indir) + conju(dir)

-N=.2-1.3 mg/dl

Question 7

Uncon Bilirubin Inc in

Answer 7

• Gilbert’s(defect uptake & storage)

- hemolysis, transfusion

Question 8

Conju bilirubin Inc in

Answer 8

• Dubin Johnson(black liver)
• Intrahepatic dis
  
  • cirrhosis, hepis,liver fail
• Extrahepatic dis
  
  • bile duct dis

Question 9

Evaluate jaundice

Answer 9

1. Diag imaging studies(US, CT)
2. MRI
3. HIDA scan(acu cholecystitis)
4. ERCP/PTC
5. Liver biopsy

Question 10

True test liver fx

Answer 10

1. Albumin
   - < in liver dis(3 week)
2. PTT
   - > in cholestasis, 1ry heptocel dysfx