W11 Xenobiotic Endocrine Disruptors

Question 1

Effect of perchlorate/thiocyanate on thyroid hormone production (fireworks, airbags)

Answer 1

Both perchlorate and thiocyanate bind to NIS , blocking iodide transporter., LESS t3
and T4 can be made and this can results in hypothyroidism,

Question 2

Effect of soy isoflavones on thyroid hormone production

Answer 2

Block the iodide to iodine conversion and so decrease the amount of T3 and T4 that can be produce

Question 3

Effect of dyes on thyroid hormone production

Answer 3

Things like FD&C red dye #3, Biphenol A have also been shown to Inhibit deiodinase activity so Decreases peripheral T3 synthesis, less T3 signaling