W10 Lactation Flashcards
Mammary Crest
White lines visible in embryo in 4 weeks,
Thick ectoderm
Primary Mammary bud
in Week 6 each a mammary crest turns into 1 bud (total 2 ) in human
Secondary Mammary bud
in Week 12, the structure is more complicated
Lactiferous ducts and Mammarry pit and Mammary gland
All form From 6 months to birth. No more growth and differentiation of XX and XY for first 2 years
Atrophic ducts -> ductal grown
Estrogen during puberty (8-13) years XX
Alveolar Growth
(singular Alveoli)
a group of Alveoli is called Lobule
Progesterone during pregnancy
Testosterones on mammogenesis
Low T inhibits mammogenesis
Adipose tissue
determines size of breast(everyone has)
Lactiferous ducts
tip of nipple duct (everyone has)
Alveolar epithelium
non secretory,
Lactocytes
are Alveolar epithelium that is changed to
secretory cells by hormones
Dopamine AKA prolactin inhibiting hormone PIH
From hypothalamus to ant pit, no prolactin from ant pit, not lactating
Mechanoreceptors in nipple
send message to hypothalamus through spine, stops dopamine (we don’t know how)
Prolactin
is synthesized in ant pit by Lactrotrphs when no dopamine
Lactocytes are activated by
Prolactin
In Milk, these materials released into milk by prolactin
There are AAs (Casein)
and Triglyceride fatty acids
Oxytocin
made in hypothalamus and moved to Post pit
Receptor on myoepithelial cells (smooth muscle)
Oxytocin secrets when
Handling baby, eye contact, smell of baby, and intercourse
Milk ejection is fragile meaning
sensitive to stress, anxiety, fatigue SO LESS OXY means you have milk but cant get out
Oxytocin binds to receptor in surface
- voltage gated Ca channel opens -> contraction
- Ca release inside cell -> contraction
If you mimic pregnancy you can Lactate, any gender
Progesterone
Estrogen
Both are in birth control pills
