W10/11 Flashcards

1
Q

What are the two types of memory?

A

Declarative: Things that can be consciously recalled/ described with words. Daily events, words and their meaning.

Nondeclarative: motor skills, associations, priming cues, puzzle solving.

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2
Q

What are the different time forms of memory?

A

Immediate- available for a very short time
Working- can be recalled a little longer
Long-term - things which are repeated often are moved here. Consolidation. Important information is regularly recalled and so maintained.

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3
Q

What is learning?

A

Learning is the process in which the nervous system acquires new information.
Depending on the type of learning, it may lead to a change in behaviour.

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4
Q

What is memory?

A

Memory is the saving and re-accessing of information which has been acquired through learning.

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5
Q

What is “imprinting” (prägung)

A

This is something that is learnt in the critical period and lasts a life-time.

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6
Q

What is instinct?

A

A behavioural response to a stimulus which doesn’t have to be learnt by every individual, but is acquired at a species level.

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7
Q

What improves learning?

A

Learning is dependent on protein synthesis, and therefore consolidation takes time.

Things that are put in categories are more easily learnt. Although we can also generate false memories.

Things that conform to learnt patterns, e.g. Chess game vs. random pieces.

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8
Q

What are some aspects of forgetting?

A

The older a memory is, the more likely it will be forgotten.

The more often something is recalled, the more likely it is that the memory will change and things will be forgotten.

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9
Q

Where are memories stored?

A

Throughout the cortex.

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10
Q

Describe an animal experiment which showed that the hippocampus in important for forming memories.

A

A mouse is put into a pool with an invisible platform. The mouse learns where the platform is and after 10 attempts, can find it directly.
Mice with the hippocampus removed cannot do this.

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11
Q

What did the case of the patient H.M. teach us.

A

It showed that the hippocampus was important for building new memories. H.M. could remember things from his past, but couldn’t build new memories. However, he could build new nondeclarative memories, i.e. motor learning.

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12
Q

Acquisition and storage of declarative information.

A

Sort-term storage: hippocampus and related structures.

Long-term storage: cortical sites, i.e. Wernicke’s area for the meanings of words, temporal cortex for objects, faces.

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13
Q

Acquisition and storage of nondeclarative information.

A

Short-term: unknown, presumably widespread.

Long-term: cerebellum, basal ganglia, premotor cortex, other motor areas.

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14
Q

Types of memory disorder.

A

antrograde (cannot remember new things)
retrograde (cannot remember things from the past)
Most famous, Alzheimer’s Disease.

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15
Q

What characteristics are observable in an Alzheimer’s patient’s brain?

A

Neurofibrilary tangles, and Amyloid plaque. Both of these cause loss of cell functioning.

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16
Q

How do older and younger brains process information differently?

A

Younger brains use a smaller area and need to work less hard.
An unpracticed older brain uses the same area, but needs to work much harder.
A trained older brain recruits other areas to help and can do the cognitive task just as well as the younger brain.

17
Q

What are some aspects of the ‘critical period’?

A

Nerve cells are joined together.
Some skills must be learnt in this phase, e.g. language. Children can hear a wide variety of sounds, this narrows down with age.
Imprining (Prägung) happens in this stage.

18
Q

What are the stages of a songbird or a baby learning to speak?

A

Sensory acquisition - sensory motor learning - Crystallized song. (deaf infants do the same, just with their hands)

19
Q

Describe the experiment with Aplysia Punctata.

A

The sea slug was chosen for its large neurons and simple structures.
Habituation (Gewönung) occurs through repeated touching of the siphon. The siphon no longer retracts.
After this, the touching of the siphon is combined with a shock to the tail. The siphon becomes sensitive again.

20
Q

Which cell is responsible for habituation (Gewönung)?

A

The motor neuron at the gill (Kiemen). This cell produces less and less neurotransmitter as it is repeatedly touched.

21
Q

Which cell is responsible for re-sensitisation?

A

The modulatory interneuron.

22
Q

Motivation also has an impact on learning. Describe.

A

A hungry participant will remember more pictures of food than furniture. A sated participant will not.

23
Q

What is long lasting increase in synapse strength called?

A

Long term potentiation (LTP)

24
Q

Long-term potentiation and Schaffer collateral-CA1 Synapses.

A

Schaffer collaterals are located in the hippocampus. When one of a pair is heavily stimulated, it displays LTP. The parallel synapse does not. LTP is synapse specific.

25
Q

What is the theory explaining how LTP occurs.?

A

Donald Hebb’s postulation stated that synaptic connections would get stronger if both pre-and post synaptic cells were stimulated at the same time. (Hebbian rule)

26
Q

Which channels are responsible for creating LTP?

A

Both AMPA and NMDA channels need to be present. AMPAs are needed to open NMDAs.

27
Q

What are silent synapses?

A

They are synapses which have only NMDAs and no AMPAs

28
Q

Mechanism behind early transient phase of LTP.

A

Both pre- and postsynapses are stimulated.
NMDA is stimulated by depolarization of post synaptic cell. Magnesium molecule is released and Ca2+ flows into cell.
Ca2+ cuases new AMPAs to be added through Protein kinase C and Ca2+ calmodulin kinase II which cause phosphrylation of substrate.

Synapse resopnds more strongly to stimulus- silent synapses can be activated.

29
Q

Mechanism behind late phase LTP.

A

Gene expression modulated by CREB.

New synapses can be built.