W 5/31

Question 1

CD16

Answer 1

FcR

Question 2

+TdT

Answer 2

ALL

Question 3

MPO+

Answer 3

AML

Question 4

t(15;17)

Answer 4

RAR (APL)

Question 5

CD5, CD20

Answer 5

CLL

Question 6

TRAP+

Answer 6

Hair cell leukemia

Question 7

t(9;22)

Answer 7

CML (BCR-ABL)

Question 8

Marked basophilia

Answer 8

CML

Question 9

What proliferates in the cortex of lymph nodes?

Answer 9

B cells

Question 10

What proliferates in the paracortex of lymph notes?

Answer 10

T cells

Question 11

t(14;18)

Answer 11

Follicular B cell lymphoma (BCL2)

Question 12

t(11;14)

Answer 12

Mantle cell lymphome (cycD1)

Question 13

t(8;14)

Answer 13

Burkitt (c-myc)

Question 14

CD15, CD30

Answer 14

Hodgkin lymphoma

Question 15

What is the function of TGF-B?

Answer 15

Fibroblast migration and proliferation, CT synthesis

Question 16

What paraneoplastic syndrome is associated with squamous cell lung cancer?

Answer 16

PTHrP - HCa

Question 17

What cell types are chromogranin+?

Answer 17

Neuroendocrine

Question 18

What are two angiogenic growth factors?

Answer 18

VEGF, FGF

Question 19

What cells are GFAP+?

Answer 19

Astrocytes (glial cells)

Question 20

CA-125

Answer 20

epithelial ovarian ca

Question 21

CA 19-9

Answer 21

Pancreatic ca

Question 22

What causes the fibrosis in cirrhosis?

Answer 22

Stellate cells secreting TGF-B

Question 23

What are Mallory bodies?

Answer 23

Damaged intermediate filaments in hepatocytes

Question 24

Middle aged woman with pruritis and signs of a vitamin A deficiency?

Answer 24

Primary biliary cholangitis

Question 25

What nutritional deficiency does isoniazid cause?

Answer 25

B6

Question 26

What is another name for B6?

Answer 26

pyridoxine

Question 27

What is a serious adverse effect of chloramphenicol?

Answer 27

Aplastic anemia

Question 28

What innervates external hemorrhoids and what veins do they drain into?

Answer 28

Inferior rectal - pudendal n

Infererior rectal - internal pudendal v + int iliac v

Question 29

What is aprepitant?

Answer 29

NK1 rec antag for nausea

Question 30

What is Lambert-Eaton syndrome? What causes it?

Answer 30

Paraneoplastic syndrome - Ab against V-gated Ca channels; SCLC

Question 31

Tx for atropine intoxication

Answer 31

physostigmine

Question 32

When do you see Howell-Jolly bodies? What are they made of?

Answer 32

Splenectomy; DNA

Question 33

When do you see Pappenheimer bodies? What are they made of?

Answer 33

Sideroblastic anemia; Fe

Question 34

What does a thumbprint sign on XR indicate?

Answer 34

Mesenteric ischemia

Question 35

What does the double-bubble sign on XR indicate?

Answer 35

duodenal atresia

Question 36

What do air fluid levels on XR indicate?

Answer 36

Small bowel obstruction

Question 37

What does T. cruzi destroy?

Answer 37

myenteric plexus

Question 38

t(11; 22)

Answer 38

Ewing sarcoma (EWS-FLI1)

Question 39

Where are Heberden nodes located?

Answer 39

DIP

Question 40

Where are Bouchard nodes located?

Answer 40

PIP

Question 41

What is rheumatoid factor?

Answer 41

Anti IgG

Question 42

What diseases are associated with HLA-DR4?

Answer 42

T1DM, RA

Question 43

What HLA loci is celiac associate with?

Answer 43

HLA-DQ2,8

Question 44

What disease is associated with HLA-B27

Answer 44

Seronegative spondyloarthropathies

Question 45

What Ab is seen in drug-induced lupus?

Answer 45

anti-histone Abs

Question 46

What T cell predominates in polymyositis?

Answer 46

CD8

Question 47

What T cell predominates in dermatomyositis?

Answer 47

CD4

Question 48

What autoAb is seen in diffuse scleroderma?

Answer 48

Anti-DNA topoisomerase I (anti-Scl 70)

Question 49

CREST syndrome autoAb?

Answer 49

anti-centromere

Question 50

Mixed CT disease autoAb?

Answer 50

Anti-u1 RNP Ab

Question 51

What cancer is associated with vinyl chloride and arsenic exposure?

Answer 51

Hepatic angiosarcoma

Question 52

S-100

Answer 52

Melanoma, Schwannoma (neural crest derivatives