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Step 1 > W 5/31 > Flashcards

W 5/31 Flashcards

1
Q

CD16

A

FcR

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2
Q

+TdT

A

ALL

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3
Q

MPO+

A

AML

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4
Q

t(15;17)

A

RAR (APL)

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5
Q

CD5, CD20

A

CLL

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6
Q

TRAP+

A

Hair cell leukemia

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7
Q

t(9;22)

A

CML (BCR-ABL)

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8
Q

Marked basophilia

A

CML

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9
Q

What proliferates in the cortex of lymph nodes?

A

B cells

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10
Q

What proliferates in the paracortex of lymph notes?

A

T cells

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11
Q

t(14;18)

A

Follicular B cell lymphoma (BCL2)

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12
Q

t(11;14)

A

Mantle cell lymphome (cycD1)

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13
Q

t(8;14)

A

Burkitt (c-myc)

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14
Q

CD15, CD30

A

Hodgkin lymphoma

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15
Q

What is the function of TGF-B?

A

Fibroblast migration and proliferation, CT synthesis

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16
Q

What paraneoplastic syndrome is associated with squamous cell lung cancer?

A

PTHrP - HCa

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17
Q

What cell types are chromogranin+?

A

Neuroendocrine

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18
Q

What are two angiogenic growth factors?

A

VEGF, FGF

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19
Q

What cells are GFAP+?

A

Astrocytes (glial cells)

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20
Q

CA-125

A

epithelial ovarian ca

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21
Q

CA 19-9

A

Pancreatic ca

22
Q

What causes the fibrosis in cirrhosis?

A

Stellate cells secreting TGF-B

23
Q

What are Mallory bodies?

A

Damaged intermediate filaments in hepatocytes

24
Q

Middle aged woman with pruritis and signs of a vitamin A deficiency?

A

Primary biliary cholangitis

25
Q

What nutritional deficiency does isoniazid cause?

A

B6

26
Q

What is another name for B6?

A

pyridoxine

27
Q

What is a serious adverse effect of chloramphenicol?

A

Aplastic anemia

28
Q

What innervates external hemorrhoids and what veins do they drain into?

A

Inferior rectal - pudendal n

Infererior rectal - internal pudendal v + int iliac v

29
Q

What is aprepitant?

A

NK1 rec antag for nausea

30
Q

What is Lambert-Eaton syndrome? What causes it?

A

Paraneoplastic syndrome - Ab against V-gated Ca channels; SCLC

31
Q

Tx for atropine intoxication

A

physostigmine

32
Q

When do you see Howell-Jolly bodies? What are they made of?

A

Splenectomy; DNA

33
Q

When do you see Pappenheimer bodies? What are they made of?

A

Sideroblastic anemia; Fe

34
Q

What does a thumbprint sign on XR indicate?

A

Mesenteric ischemia

35
Q

What does the double-bubble sign on XR indicate?

A

duodenal atresia

36
Q

What do air fluid levels on XR indicate?

A

Small bowel obstruction

37
Q

What does T. cruzi destroy?

A

myenteric plexus

38
Q

t(11; 22)

A

Ewing sarcoma (EWS-FLI1)

39
Q

Where are Heberden nodes located?

A

DIP

40
Q

Where are Bouchard nodes located?

A

PIP

41
Q

What is rheumatoid factor?

A

Anti IgG

42
Q

What diseases are associated with HLA-DR4?

A

T1DM, RA

43
Q

What HLA loci is celiac associate with?

A

HLA-DQ2,8

44
Q

What disease is associated with HLA-B27

A

Seronegative spondyloarthropathies

45
Q

What Ab is seen in drug-induced lupus?

A

anti-histone Abs

46
Q

What T cell predominates in polymyositis?

A

CD8

47
Q

What T cell predominates in dermatomyositis?

A

CD4

48
Q

What autoAb is seen in diffuse scleroderma?

A

Anti-DNA topoisomerase I (anti-Scl 70)

49
Q

CREST syndrome autoAb?

A

anti-centromere

50
Q

Mixed CT disease autoAb?

A

Anti-u1 RNP Ab

51
Q

What cancer is associated with vinyl chloride and arsenic exposure?

A

Hepatic angiosarcoma

52
Q

S-100

A

Melanoma, Schwannoma (neural crest derivatives

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