Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step 1 > M 5/29 > Flashcards

M 5/29 Flashcards

1
Q

What does the dorsal pancreatic bud become?

A

The pancreatic body, tail, most of head, accessory duct

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does the ventral pancreatic bud become?

A

Uncinate process, portion of head, proximal portion of main duct

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What cells express HLA I?

A

All nucleated cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What cells express HLA II?

A

Antigen presenting cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What do HLA I present?

A

Endogenous peptides to CD8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do HLA II present?

A

Foreign antigens to CD4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What mutation is associated with MODY?

A

Glucokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What enzyme functions as a glucose sensor in B cells?

A

Glucokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is insulin release stimulated by?

A

Inc in ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does bradykinin do?

A

Dilates blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What occurs in C1 esterase inhibitor deficiency?

A

Unregulated kallikrein leads to an inc in bradykining; hereditary angioedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What drugs are contraindicated in C1INH def

A

ACEI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What enzyme degrades bradykinin?

A

ACE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the mechanism of action of hydralazine

A

Inc cGMP –> sm m relaxation; arterioles > veins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What effect does hydralazine have on afterload?

A

Dec

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is hydralazine used for?

A

Severe/acute HTN

17
Q

Hydralazine has a mortality benefit in HF when combined with what?

A

Nitrate

18
Q

Is hydralazine safe in pregnancy?

A

Yes

19
Q

How do you prevent reflex tachy w hydralazine?

A

Administer w a B blocker

20
Q

How do the glitazones work?

A

Bind PPAR-g nuclear receptor; inc adiponectin; inc insulin sensitivity, FA oxidation, GLUT4 in peripheral tissues, inc TG storage/dec serum TG

21
Q

What are the adverse effects of glitazones?

A

weight gain, edema, hepatoxicity, HF, inc risk of fx

22
Q

V1 vasopressin rec

A

Gq - vasoconstriction, inc BP

23
Q

V2 vasopressin rec

A

Gs - CD - H20 permeability (aquaporin) and reabs; vascular endothelium - vwF, F8 release

24
Q

How do you calculate FF?

A

FF = GFR/RPF (N = 20%)

25
Q

Cr clearance =

A

GFR

26
Q

PAH clearance =

A

RPF

27
Q

What is indomethacin used for?

A

Close PDA, acute gout, nephrogenic DI

28
Q

How do you keep a PDA open?

A

PGE analogs

29
Q

What is the inheritance of Peutz-Jeghers

A

AD

30
Q

What are the features of Peutz-Jeghers?

A

Hamartomatous GI polyps, hyperpigmentation of hands/mouth/feet/genitals

31
Q

What are Charcot-Bouchard microaneurysms associated with? Where do they occur?

A

Chronic HTN, small vessels (basal ganglia, thalamus)

32
Q

What are the features NMS?

A

Rigidity, myoglobinuria, autonomic instability, hyperpyrexia

33
Q

How do you treat NMS?

A

Dantroline, D2 agonist (bromocriptine)

34
Q

What drugs cause NMS?

A

Antipsychotics

35
Q

What does Fanconi anemia often progress to?

A

AML

Step 1 (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions