VTE Flashcards
Inpatient VTE prophylaxis: what is it important to know/ ask about?
Any current bleeding/ bleeding risk
Weight + renal function (reduced dose if <50kg)
Clinical features of PE
Dyspnoea, tachypboea, pleuritic chest pain
May also have features of DVT
Less common features of PE
Retrosternal chest pain (due to RV ischaemia)
Cough + haemoptysis
Signs of PE: HR O2 sats temperature JVP Sound BP
TachyC Hypoxia Pyrexia Raised JVP Pleural rub Hypotension
What is a massive PE?
Involves both pulmonary arteries OR results in haemodynamic compromise
What is a provoked PE?
Risk of recurrence
Associated with a transient RF
RFs can be removed = reduced risk of recurrence
What is an unprovoked PE?
Risk of recurrence
No identifiable RFs
Inc risk of recurrence
Pathophysiology of PE
Effect on pulmonary artery
Lung tissue is ventilated but not perfused = intrapulmonary dead space + impaired gas exchange
increased pulmonary artery pressure
Most common cause of PE
DVT
Other causes of PE (think sources)
Tumours Fat Amniotic fluid Sepsis Foreign body Air
Tumours most likely to cause PE
Prostate + breast
Most common cause of a fat PE
long bone fractures
Most common cause of an air PE
Surgery
6 major risk factors for PE
DVT (70%) Active cancer Recent surgery (last 2 months) Immobility Lower limb trauma/ fracture Pregnancy + 6 weeks pp
What % of PEs have no identifiable RFs?
30-50%
How much does having an active cancer increase the risk of VTE?
4 fold risk
Other RFs for VTE
Age >60
COCP
Obesity
Long-haul travel/ thrombotic disorders/ varicose veins