Overdose Flashcards
What resource is good to look up management of OD?
TOXBASE
Paracetamol OD causes the build up of what toxic metabolite?
NAPQI
Define a staggered OD
OD taken over >1 hour
What amount of paracetamol = significant toxicity?
> 150 mg/kg
Give 2 factors increasing the risk of liver damage in paracetamol OD
Malnutrition and alcohol (previous damage)
How may paracetamol OD present (<24 hours)
Nausea, vomiting, sweating
abdo pain?
What are the late signs of paracetamol OD? (i.e. if untreated)
Liver failure!!
Jaundice, confusion, coagulopathy, hypoglycaemia
After 3-5 days
When should you measure plasma levels of paracetamol
After 4 hours
If someone presents <1 hour post-paracetamol OD, what can you give them?
Activated charcoal 1g/kg
What do you give for paracetamol OD as soon as you get the 4 hour reading back?
NAC (N-acetylcysteine)
When is NAC most effective?
<8 hours
How is NAC given?
24 hour infusion
How does NAC work?
Increases the amount of glutathoine so NAPQI can be broken down
Do you still give NAC if paracetamol OD presents late?
YES!!
Someone presents 8-24 hours post-paracetamol OD - what do you give them?
NAC straight away!
If the amount is >150mg/kg, even before the serum conc comes back
How do you manage a staggered OD?
Give NAC immediately if amount >150 mg/kg - serum levels not reliable in this context
What triclyclic is most likely to cause lethal intoxication?
1st generation (e.g. amitriptyline)
What are the anti-cholinergic features of tricyclic OD?
these present early
Dry mouth Dilated pupils Tachycardia Urinary retention Myoclonic jerks Blurred vision Hypotension
Is the response in tricyclic OD sympatetic or parasympathetic?
SYMPATHETIC response because it blocks parasympathetic
What are the effects of blocking sodium channels in tricyclic OD?
Cardiac arrhythmias + seizures