Vsiculo-Bollous Flashcards
Definition of PATHOPHYSIOLOGY
the physiology of abnormal states; specifically : the functional changes that accompany a particular syndrome or disease
Definition of ETIOLOGY
plural etiologies
1: CAUSE, ORIGIN; specifically : the cause of a disease or abnormal condition
2: a branch of knowledge concerned with causes; specifically : a branch of medical science concerned with the causes and origins of diseases
Definition of PATHOGENESIS
the origination and development of a disease
1) Vesicle
2) Bulla
3) Erosion
4) Ulcer
1) Vesicle - fluid, <0.5
2) Bulla -fluid, >0.5
3) Erosion - no size, many colors
4) Ulcer -all layers of epi gone with microscopic death of cells
ramsay hunt syndrome
caused by herpetic zoster
*sever unilateral facial palsey
steroids indicated or not for zoster infections?
NOT indicated
Zoster vs Simplex
Zoster- unilateral, longer duration must treat acyclovir
Simplex- bilateral, shorter duration
hand-foot-mouth virus?
piconavirus, part of Coxsackie
Herpangina virus?
Coxsackie type A
Measels
Paramyxovirus
KOpliks spots
RubeOla
Warthin-Finkeldey giant cells (macrophages)
German Measels
Germans eat nutELLA (Rubella) while wearing TOGAS (virus) and kill (abort) babies
**NO Kopliks spots
MMP
sexes? appearance? histo?
women more
bright red patches, short lived, rare bullae
Nikolsky’s sign
epithelial clefting
pemphigus vs MMP you see what antibodies?
Pemphigus: IgG &C3
MMP: IgG, C3 AND IgA
Tzank cells
large glassy nucleus’s
Herpes, Varicella Zoster, PV
Warthin-Finkeldey giant cells
multinucleated giant cells in lymph tissue from measels (rubeola)
1) Pemphigus hyper?
2) pemphigoid?
3) TB
4) EM
5) drugs
6) angio edema
7) stomatitis Venenata
1) Pemphigus hyper? type 2
2) pemphigoid? type 2
3) TB type 4
4) EM type 2 or 3
5) drugs = IgE type 1
6) angio edema type 1
7) stomatitis Venenata type 3 or 1
1) pemphigus targets?
2) pemphegoid?
3) epidermolysis bullosa? herditary
4) MMP
1) desmoglein 3
2) BMZ and hemodesmosomes
3) collagen of anchoring fibrils
4) laminin 5 (epiligrin)
symblepharon
Scar at the canthus from MMP
entropion
inversion of the Eyelashes from MMP
trichiasis
Trauma to cornea from MMP
PV age? phenotypes? sexes? severe form?
40-50 years equal between sexes HLA phenotypes nikoskys sign paraneoplastic pemphigus is sever form/malignant
nikolsky’s sign?
PV and MMP