Vsiculo-Bollous Flashcards
Definition of PATHOPHYSIOLOGY
the physiology of abnormal states; specifically : the functional changes that accompany a particular syndrome or disease
Definition of ETIOLOGY
plural etiologies
1: CAUSE, ORIGIN; specifically : the cause of a disease or abnormal condition
2: a branch of knowledge concerned with causes; specifically : a branch of medical science concerned with the causes and origins of diseases
Definition of PATHOGENESIS
the origination and development of a disease
1) Vesicle
2) Bulla
3) Erosion
4) Ulcer
1) Vesicle - fluid, <0.5
2) Bulla -fluid, >0.5
3) Erosion - no size, many colors
4) Ulcer -all layers of epi gone with microscopic death of cells
ramsay hunt syndrome
caused by herpetic zoster
*sever unilateral facial palsey
steroids indicated or not for zoster infections?
NOT indicated
Zoster vs Simplex
Zoster- unilateral, longer duration must treat acyclovir
Simplex- bilateral, shorter duration
hand-foot-mouth virus?
piconavirus, part of Coxsackie
Herpangina virus?
Coxsackie type A
Measels
Paramyxovirus
KOpliks spots
RubeOla
Warthin-Finkeldey giant cells (macrophages)
German Measels
Germans eat nutELLA (Rubella) while wearing TOGAS (virus) and kill (abort) babies
**NO Kopliks spots
MMP
sexes? appearance? histo?
women more
bright red patches, short lived, rare bullae
Nikolsky’s sign
epithelial clefting
pemphigus vs MMP you see what antibodies?
Pemphigus: IgG &C3
MMP: IgG, C3 AND IgA
Tzank cells
large glassy nucleus’s
Herpes, Varicella Zoster, PV
Warthin-Finkeldey giant cells
multinucleated giant cells in lymph tissue from measels (rubeola)
1) Pemphigus hyper?
2) pemphigoid?
3) TB
4) EM
5) drugs
6) angio edema
7) stomatitis Venenata
1) Pemphigus hyper? type 2
2) pemphigoid? type 2
3) TB type 4
4) EM type 2 or 3
5) drugs = IgE type 1
6) angio edema type 1
7) stomatitis Venenata type 3 or 1
1) pemphigus targets?
2) pemphegoid?
3) epidermolysis bullosa? herditary
4) MMP
1) desmoglein 3
2) BMZ and hemodesmosomes
3) collagen of anchoring fibrils
4) laminin 5 (epiligrin)
symblepharon
Scar at the canthus from MMP
entropion
inversion of the Eyelashes from MMP
trichiasis
Trauma to cornea from MMP
PV age? phenotypes? sexes? severe form?
40-50 years equal between sexes HLA phenotypes nikoskys sign paraneoplastic pemphigus is sever form/malignant
nikolsky’s sign?
PV and MMP
BP (bullous pemphihoid)
related to? differs how?
related to MMP
deffers bc detachment antigens are laminin, BP230and BP180
*old poeple 70-80, skin and oral
EB (epidermolysis Bullosa)
forms? nails?
aquired form and genetic (can only do direct if genetic)
dystophic nails
heals with scars
red mouth
PV EB erythema multiform steven johnsons EM
factitial
self induced traumatic ulcer
riga-fede disease
mechanical traumatic ulcer due to baby being born with teeth and biting
necrotizing sialometaplasia
ONLY in palate - death of salivary gland
syphillus caused by
treponema pallidum
primary, secondary and tertiary syphillus
primary- chancre
secondary- condyloma latum, oral mucous pathces, maculopapular rash
tertiary- gumma, mucosal atrophy, cardio and neuro
congenital syphillus
saddle nose
saber shin
hutchinson’s triad (mulberry molars, scredriver incisors, 8th nearve deafness, keratitis)
fellatio?
seen in?
oral stimulation of a man’s penis
*seen in gonorrhea caused by neisseria gonorrhoeae
Langhans giant cells seen in? describe disease
TB
- tongue and palate non-healing ulces
- central caseous necrosis
what has inuration?
TB
cancer
actinomycosis
Actinomycosis
discharge? bacteria? histo?
discharge sulfer granules
gram + anaerobic
basophilic core with eosinophilic periphery
histoplasmosis
deep fungal from bat and pigeon droppings
coccidioidomycosis
deep fungal from desert soil
blastomycosis
deep fungla from moist soil and mold
cryptococcosis
deep fungal from avian poop (Cry of the Bird)
minor aphthae vs major aphthae vs herpatiform
minor- 1-5 small, mobile, NO scar, symetric
major- mobile, YES scar, assymetric, larger
herpatiform- 10-100 small ulcers, anywhere, symetric
debacterol
chemical cautery used for aphthous ulcers
granulomas happen in?
chrons, TB, syphillis, histoplasmosis, all deep fungal
Behcet’s syndrome?
more common in men
brother to aphthous ulcers, more serious
T-lymph infiltrate
EM (erythema multiforme)
minor vs major? lesions?
type 3
- minor- infections
- major- drugs
- bilateral recurrent bullseye lesions
- short duration and acute
- ANYWHERE but avoids gingiva
angioedema
IgE type 1
- heriditary= C1 esterase defeciency
- induced= ACE inhibitor
stomatitis Venenata
direct contact with allergin
stevens johnson syndrome
mouth, eyes, skin, genitals
*sever form of EM
lichenoid drug reactions
Ex? Histo?
non-specific
- liquifaction of basal cells
- perivascular
- scattered eosinophils
Example is stomatitis venenata (direct contact and type 3)
wegener’s granulomatosis
Classes? Characteristics?
- strawberry ginigvitus to attached gingiva
- antineutrophil cytoplasmic antibodies and multinucleated giant cells
- palatal perferation
- 3 classes: classic (renal), limited (resp). superficial
candidal leukoplakia is premalignant why?
makes nitrosamines
TNM for tumor staging means?
T= tumor N= node M= metastasis
low vs high grade SCC
low= well defferenciated
high= poor differenciation worse
SCC stage prognosis
1/2 = 76% 3= 41% 4= 9%
3 parts to osteoradionecrosis?
*how to prevent?
1) hypoxia
2) hypovascular
3) hypocellar
* prevent with hyperbaric oxygen (more common in MAndible)
Midline granuloma vs contact allergies
midline= Malignancy of t-lymphocytes
Contact allergies= t-cell mediated immune response
