von willebrand factor Flashcards
1
Q
von Willebrand disease?
A
- genetic disorder caused by missing or defective von willebrand factor
- most common bleeding disorder
2
Q
roles of VWF
A
- binds factor 8
- assists activated platelet aggregation
3
Q
faulty gene of VWD is on chromosome number…
A
12
4
Q
occurence of VWD in men and women?
A
equal occurence
5
Q
consequences of VWD
( what does it impact?)
A
- defects in platelets function
- low factor 8
- affects primary + secondary haemostasis
6
Q
treatment for VWD
A
- Rx with desmopressin
- infusions contain factor 8 & vWF
7
Q
symptoms of VWD
A
- menorrhagia
- bleeding from mucous membranes
- bleeding from wounds
8
Q
type 1 VWD
A
- 70% of cases
- autosomal dominant
- mild disease
- quantitative defects
9
Q
type 2 VWD
A
- 25% of cases
- autosomal dominant
- mild-moderate disease
- qualitative defects
10
Q
type 3 VWD
A
- 5% of cases
- autosomal recessive
- severe disease
- deletions/mutations
