Vomiting and malabsorption Flashcards

1
Q

Describe the pre-ejection phase in vomiting?

A

□ Pallor
□ Nausea
□ Tachycardia

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2
Q

Describe the ejection phase of vomiting

A

□ Retch

□ Vomit

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3
Q

Describe the post-ejection phase in vomiting

A

□ Floppy
□ Lethargic
□ Pale

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4
Q

What stimulates the vomiting centre in children?

A
□ Enteric pathogens
□ Intestinal inflammation
□ Metabolic derangement
□ Infection
® UTI
® Meningitis
® Encephalitis 
® Cellulitis 
® Sepsis
□ Head injury
□ Visual stimuli
□ Middle ear stimuli
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5
Q

Describe billous vomiting and its causes?

A
  • Should always ring alarm bells
  • Due to intestinal obstruction until proved otherwise
  • Causes
    □ Intestinal atresia (in new-born babies only)
    □ Malrotation +/- volvulus
    □ Intussusception (part of the bowel “telescopes” into another part of the bowel)
    □ Ileus
    □ Crohn’s disease with strictures
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6
Q

What investigations should be done in a child with bilious vomiting?

A

□ Abdominal x-ray
□ Consider contrast meal
□ Surgical opinion re exploratory laparotomy

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7
Q

Explain effortless vomiting

A
  • This is almost always due to gastro-oesophageal reflux
  • Very common problem in infants
  • Self-limiting and resolves spontaneously in the vast majority of cases
  • A few exceptions:
    □ Cerebral palsy
    □ Progressive neurological problems
    □ Oesophageal atresia +/- TOF operated
    □ Generalised GI motility problem
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8
Q

Describe test feeding

A

○ Palpation of “olive” tumour
○ Visible gastric peristalsis
- Thickened pylori- the stomach is trying to push the food through
○ Projectile non bilious vomiting

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9
Q

What is pyloric stenosis?

A
○ Babies 4-12 weeks
○ Boy> girls
○ Projectile non-bilious vomiting
○ Weight loss
○ Dehydration +/- shock
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10
Q

What are the charecteristic electrolyte desturbances in pyloric stenosis?

A

® Metabolic alkalosis (increased pH)
® Hypochloraemia
® Hypokalaemia

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11
Q

What is the management of pyloric stenosis?

A

® Fluid resuscitation
® Refer to surgeons
□ Ramstedts pyloromyotomy

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12
Q

What are the presenting syndromes of gastric oesophageal reflux?

A
® Gastrointestinal
□ Vomiting
□ Haematemesis
® Nutritional
□ Feeding problems
□ Failure to thrive
® Respiratory
□ Apnoea
□ Cough
□ Wheeze
□ Chest infections
® Neurological
□ Sandifer’s syndrome
® Spastic and dystonic body movements 
® Nodding and rotation of the head
® Neck extension 
® Gurgling sounds
® Withering movements of the limbs
® Severe hypotonia
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13
Q

How is gastric oesophageal reflux medicaly assessed?

A
® History & examination often sufficient
® Radiological investigations
□ Video fluoroscopy
□ Barium swallow
® pH study
® Oesophageal impedance monitoring
® Endoscopy
□ Severe symptoms
□ If reflux hasn't resolved after 2 years of life
□ Neurodisability
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14
Q

What might barium swallow show you?

A
◊ Dysmotility
◊ Hiatus hernia
◊ Reflux
◊ Gastric emptying
◊ strictures
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15
Q

What are problems that could happen in a barrium swallow?

A

◊ Aspiration

◊ Inadequate contrast taken (NG tube)

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16
Q

What is the treatment of gastric oesophageal reflux?

A
  • Feeding advice
  • Nutritional support
  • Medical treatment
    □ Feed thickener
    ® Gaviscon
    ® Thick & Easy
    □ Prokinetic drugs
    □ Acid suppressing drugs
    ® H2 receptor blockers
    ® Proton pump inhibitors
  • Surgery
17
Q

What feeding advise is given to children with gastric oesophageal reflux?

A
□ Thickeners for liquids
□ Appropriateness of foods
® Texture
® Amount
□ Behavioural programme
® Oral stimulation 
® Removal of aversive stimuli
□ Feeding position
18
Q

What nutritional support is given to children with gastric oesophageal reflux?

A

□ Calorie supplements
□ Exclusion diet (milk free)
□ Nasogastric tube
□ Gastrostomy

19
Q

What are the indications for surgery in children with gastro oesophageal reflux?

A
® Failure of medical treatment
® Persistent:
◊ Failure to thrive
◊ Aspiration 
◊ Oesophagitis
® Vomiting without complications may not be an indication
20
Q

What is the definition of chronic diarrhoea?

A
® 4 or more stools per day
® For more than 4 weeks
® A little contentious, lots of definitions exist!
® <1 week: acute diarrhoea
® 2 to 4 weeks: persistent diarrhoea
® >4 weeks: chronic diarrhoea
21
Q

What are the causes of diarrhoea?

A
® Motility disturbance
□ Toddler Diarrhoea
□ Irritable Bowel Syndrome
® Active secretion	 (secretory)
□ Acute Infective Diarrhoea
® Cholera is the commonest  
□ Inflammatory Bowel Disease
® Malabsorption of nutrients (osmotic)
□ Food Allergy
□ Coeliac Disease
□ Cystic Fibrosis
22
Q

What is osmotic diarrheoa?

A

® Movement of water into the bowel to equilibrate osmotic gradient
® Usually a feature of malabsorption
□ Enzymatic defect
□ Transport defect
® Mechanism of action of lactulose/movicol
® Generally accompanied by macroscopic and microscopic intestinal injury
® Clinical remission with removal of causative agent

23
Q

What is secretory dairrhoea?

A

® Classically associated with toxin production from Vibrio cholerae and enterotoxigenic Escherichia coli
□ In cholera, can lose 24L per day!
® Intestinal fluid secretion predominantly driven by active Cl- secretion via CFTR

24
Q

What is motility diarrhoea?

A
® Pretty straightforward!
® Classically toddler’s diarrhoea
® Other causes
□ Irritable bowel syndrome
□ Congenital hyperthyroidism
□ Chronic intestinal pseudo-obstruction
25
Q

What is inflammatory diarrhoea?

A

® “Mixed bag” really
® Malabsorption due to intestinal damage
® Secretory effect of cytokines
® Accelerated transit time in response to inflammation
® Protein exudate across inflamed epithelium

26
Q

What should be asked about in the history of a child with chronic diarrhoea?

A

□ Age at onset
□ Abrupt/gradual onset
□ Family history
□ Nocturnal defecation suggests organic pathology
□ Consider growth and weight gain of child

27
Q

What is faeces analysis?

A

□ Appearance
□ Stool culture
□ Determination of secretory vs. osmotic
® Stop the feed: if the diarrhoea stops then it is osmotic

28
Q

What causes fat malabsorption?

A
○ Pancreatic Disease
® Diarrhoea due to lack of lipase and resultant steatorrhea
® Classically cystic fibrosis
○ Hepatobiliary Disease
® Chronic liver disease
® Cholestasis
○ Coeliac disease
29
Q

What is coeliac disease?

A

® Gluten sensitive enteropathy

® Affects 1% of the western population

30
Q

What are the features of coeliac disease?

A
□ Abdominal belatedness
□ Diarrhoea
□ Failure to thrive
□ Short stature
□ Constipation
□ Tiredness
□ Dermatitis herpetiform
31
Q

What genes makes someone susceptable to coeliac disease

A

□ DQ2

□ DQ8

32
Q

What are the tests for coeliac disease?

A
□ Serological Screens
® Anti-tissue transglutaminase
® Anti-endomysial
® Anti-gliadin (don’t check anymore)
® Concurrent IgA deficiency in 2% may result in false negatives
□ Gold standard-  duodenal biopsy
□ Genetic testing
® HLA DQ2, DQ8
33
Q

When can coeliac disease be diagnosed without a biopsy?

A

□ Symptomatic children
□ Anti TTG >10 times upper limit of normal
□ Positive anti endomysial antibodies
□ HLA DQ2, DQ8 positive

34
Q

What is the treatment for coeliac disease?

A

□ Gluten-free diet for life
□ Gluten must not be removed prior to diagnosis as serological and histological features will resolve
□ In very young <2yrs, re-challenge and re-biopsy may be warranted
□ Increased risk of rare small bowel lymphoma in untreated