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Volatiles Flashcards

1
Q

What is the MAC of halothane

A

0.75

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2
Q

What is halothanes OGPC

A

224

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3
Q

Halothanes blood:gas cooefficient

A

2.4

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4
Q

What is halothanes boiling point

A

50

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5
Q

What is halothanes SVP

A

32

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6
Q

What are halothanes side effects

A

Bronchodilator
Reduced CO
Increase CBF
Hepatitis (more in adults -> necrosis)

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7
Q

How is halothane metabolised

A

20% via CYP450 to trifluoroacetic acid, chlorine, bromine

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8
Q

What type of chemical is halothane

A

Halogenated hydrocarbon
Unstable in light

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9
Q

What is the MAC of isoflurane

A

1.17

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10
Q

What is isofluranes OGPC

A

98

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11
Q

What is isofluranes blood gas coefficient

A

1.4

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12
Q

What is isofluranes boiling point

A

48

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13
Q

What is the SVP of isoflurane

A

33

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14
Q

What are isofluranes effects

A

airway irritant
reduced SVR (?coronary steal)
Best CBF profile (no increase if <1MAC)

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15
Q

What is isofluranes metabolism

A

0.2% hepatic to trifluoroacetic acid and fluorides.
CHF2 and sodalime might -> CO

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16
Q

What type of chemical is isoflurane

A

Halogenated ethyl methyl ether

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17
Q

What is enfluranes MAC

A

1.68

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18
Q

What is enfluranes OGPC

A

98

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19
Q

What is enfluranes BGPC

A

1.8

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20
Q

What is the boiling point of enflurane

A

56

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21
Q

What is the SVP of enflurane

A

23

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22
Q

What are enfluranes side effects

A

At high concentrations get a 3Hz spike in EEG similar to seizure

23
Q

What is the metabolism of enflurane

A

2% to fluorides which can cause nephropathy.
CHF2 and sodalime might -> CO

24
Q

What is sevofluranes MAC

25
Q

What is sevofluranes OGPC

26
Q

What is sevofluranes BGPC

27
Q

What is sevofluranes boiling point

28
Q

What is sevofluranes SVP

29
Q

What are sevofluranes side effects

A

Reduced SVR

30
Q

What is sevofluranes metabolism

A

3.5% via CYP2E1
Fluorides and soda lime -> compound A

31
Q

What type of chemical is sevoflurane

A

Polyfluorinated isopropyl methy ether
Achiral

32
Q

How is sevo stored and why

A

In polyethylene napthalate with 300ppm water
If stored with <100ppm water/ in glass -> lewis acids -> hydrofluoric acid

33
Q

What is desflurane’s MAC

34
Q

What is desfluranes OGPC

35
Q

What is desfluranes BGPC

36
Q

What is desfluranes boiling point

37
Q

What is desfluranes SVP

38
Q

What are desfluranes side effects

A

Quick onsent/offset
Tachycardia
HTN

39
Q

What is desfluranes metabolism

A

0.02% to trifluoroacetic acid
CHF2 + soda lime -> CO

40
Q

What are the TEC 6 conditions?

A

Heated to 39 at 2bar

41
Q

What is N2Os MAC

42
Q

What is the OGPC of N2O

43
Q

What is the BGPC of N2O

44
Q

What is N2Os BP

45
Q

What is the SVP of N2O

46
Q

What are the side effects of N2O

A

Increase CBF
Myocardial depression but SNS stimulation
PONV
Agranulocytosis

47
Q

How is N2O metabolised

A

<0.01% to N2
B12 cobalt oxidised -> megaloblastic changes

48
Q

What is N2Os critical temp and pressure

A

36.5 and 72

49
Q

What is xenons MAC

50
Q

What is the OGPC of xenon

51
Q

What is the BGPC of Xenon

52
Q

What is xenon’s BP

53
Q

What are Xenon’s side effects

A

Decrease HR and RR
Increases TV (opp. to the rest)
Analgesia

54
Q

How is xenon metabolised

A

Eliminated in the lungs

Primary Pharm (4 decks)

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