Induction Agents

Question 1

What is propofol protein binding

Answer 1

98%

Question 2

How is propofol metabolised?

Answer 2

Hepatic to non-active metabolites. High ER

Question 3

What is propofol’s clearance

Answer 3

25ml/kg/min

Question 4

What is the plasma propofol level for maintenance

Answer 4

4-8microg/ml

Question 5

What is the dose of thiopentone

Answer 5

3-7mg/kg

Question 6

How is propofol presented

Answer 6

1 or 2% lipid emulsion
Weakly acidic, pKa 11

Question 7

How is thiopentone presented

Answer 7

Sodium salt yellow powder in nitrogen. Makes an alkaline solution with pH 10.5 at 2.5% (to prefer the enol version)

Question 8

What is the pKa of thiopentone

Answer 8

7.6…60% of free form is unionised

Question 9

What is the protein binding of thiopentone

Answer 9

80% protein bound

Question 10

How is thiopentone metabolised?

Answer 10

It is rapidly redistributed. Hepatically metabolised to pentobarbital. Low hepatic ER
P450 inducer

Question 11

What is thiopentones clearance

Answer 11

3.5ml/kg/min

Question 12

What is the dose of etomidate

Answer 12

0.3mg/kg

Question 13

How is etomidate presented

Answer 13

0.2% solution pH 4.1

Question 14

What is the protein binding of etomidate

Answer 14

75%

Question 15

How is etomidate metabolised

Answer 15

Hepatic to inactive metabolites

Question 16

Whats the clearance of etomidate

Answer 16

10-20ml/kg/min

Question 17

What is the dose of ketamine

Answer 17

1-2mg/kg IV
5-10mg/kg IM
Sedation 0.2-0.5mg/kg

Question 18

How is ketamine presented

Answer 18

Racemic mix or S enantiomer
Acid solution

Question 19

What is the protein binding of ketamine

Answer 19

25%

Question 20

How is ketamine metabolised

Answer 20

Hepatic - P450 to norketamine (30% as potent)

Question 21

What is the clearance of ketamine

Answer 21

17ml/kg/min