vitiligo Flashcards
what is vitiligo
non infectiious
genetically predisposed diseease
associated with the loss of melanocytes
C/P of vitiligo ?
well circumscribed
milky white
patches
primary lesions are either macules or patches
may affect skin or the scalp andd result in poliosis
what are the different theories for the etiology of vitiligo ?
neurogenic theory
autoimmune theory
contact or chemical theory
oxidant-antioxidant imbalance
how is the autoimmune theory proven ?
by the association of other autoimmune diseases such as
Diabetes
autoimmune thyroiditis
pernicious anemia
clinical types of vitiligo
localized
segmental
acrofacial
generalized
universalis
ddx of vitiligo ?
tinea versicolor
pityrasis alba
post inflammatory hypopigmentation
what are the 2 main tx stratergies for vitiligo ?
repigmentation
or
depigmentation - in vitiligo universalis
how is repiigmentation achieved
phototherapy / photochemotherapy
medical treatment
surgical treatment
camouflage
how is depigmentation achieved ?
Phenolic compounds
hydroquinone derivatives
LASER
phototherapy
PUVA
Narrow Band UVB 311nm
Targeted UVB 308 nm
medical treatment ?
steroids
immunomodulators - tacrolimus
antioxidants
surgical treatment
punch grafting
