Vitamins Flashcards
Fat soluble vitamins
A, D, E, K
Dependent on ileum and pancreas
Can be more toxic than water-soluble vitamins because FAT-SOLUBLE ADEK can accumulate in fat
watr soluble vitamins
B1 B2 B3 B5 B6 B7 B9 B12 C
there is no 4 and 8
- A cofactor for several dehydrogenase reactions ?
- Name examples of these dehydrogenase reactions?
1.Thiamine B1
Branched chain ketoacid dehydrogenase
alpha-keoglutarate dehydrogenase (TCA cycle)
Pyruvate Dehydrogenase (TCA cycle)
Transketolase (HMP shunt)
Impaired glucose breakdown affects the production of
ATP
Dilated cardiomyopathy
high cardiac output, edema
Wet
Beriberi
B1 defficiency
Amnestic disorder due to alcohol consumption, presents with confabulation, personality changes and memmory loss (permanent)
Korsakoff syndrome
Damage to medial dorsal nucleus of thalamus, mammillary bodies. Presentation is combination of Wernicke encelopathy and Korsakoff syndrome
Wernicke-Korsakoff syndrome
Polyneuropathy with symmetric muscle wasting
DRY
Beriberi
Acute life threatening, neurologic condition, classic triad of confusion, opthalmoplegia , ataxia
Wernicke encelopathy
B1 defficiency
Component of FLAVINS FAD and FMN
* used as cofactors in REDOX reactions
Name a n enzyme reaction in which B2 is important
Vitamin B2
(Riboflavin)
Succinate Dehydrogenase (TCA)
A defficiency due to lack of B2
Cheliosis
(inflammation of the lips, scaling, fissures at the corner of the mouth)
Corneal vascularization
key: 2 Bs (B2) 2 Cs
A constituent of NAD+ and NADP+
(used in redox reactions)
Vitamin D
calcium homeostasis
D2 Ergocalciferol
D3 active Cholicalciferol
1st and 2nd hydroxilation
not easily absorbed in an activated form
activated in kidneys via hydroxylation
Food: dairy products
Sunlight: activate vit D
deficiency:
child: rickets
adult
Retinol
Vit A
Vision (opsins: photoreceptors composed of A
Acne treatment:
Vit A: normal differentition of
Ascorbic Acid
Vitamin C
active form : vitamin C
related deficiencies:
help make collagen
