Vitamin B1/B2/B3 Flashcards

1
Q

Which two vitamin groups are water-soluble?

A

B-Complex Vitamin’s & Vitamin C

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2
Q

Vitamin B1 is also known as?

A

Thaimin

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3
Q

The structure of vitamin B1 (Thiamin) is known for what two components?

A

Pyrimidine + Thiazole

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4
Q

What is the coenzyme forms of vitamin B1 (Thiamin)?

A

TDP & TPP

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5
Q

What are some prominent sources of vitamin B1 (Thiamin)?

A

Yeast
Pork
Legumes
Whole / Enriched Grains
Sunflower Seeds

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6
Q

How does TDP/TPP (vitamin B1) function as a coenzyme?

A

Catalyzing Decarboxylation of:
Pyruvate & a-ketoglutarate
(KREBS Cycle)

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7
Q

What are the coenzyme reactions of vitamin B1 important for?

A

The release of energy from food in formation of ATP

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8
Q

In an additional function of vitamin B1, TDP is needed for ______ which forms what?

A

Transketolase > forms Pentoses

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9
Q

What are Pentoses used for?

A

Synthesis of Nucleic Acids for RNA/DNA

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10
Q

Vitamin B1 is also essential for _______ Conduction

A

Nerve

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11
Q

Beriberi is a form of ____ Deficiency

A

Vitamin B1

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12
Q

What are symptoms of Beriberi?

A

Dry: Muscle Weakness & Wasting
Wet: Heart Failure with Edema

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13
Q

Wernicke-Korsakoff Syndrome is a form of _____ Deficiency

A

Vitamin B1

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14
Q

Wernicke-Korsakoff Syndrom is associated with?

A

Alcoholism

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15
Q

Wernicke-Korsakoff Syndrom will commonly result in what with relation to Thaimin?

A

Decreased Intake
Decreased Absorption

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16
Q

What population is most at risk for Wernicke-Korsakoff syndrome?

A

Elderly

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17
Q

Large doses of Vitamin B1 supplementation can be helpful with?

A

MSUD (Maple Syrup Urine Disease)

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18
Q

What is an assessment for Vitamin B1?

A

Erythrocyte Transketolase Activity

19
Q

Vitamin B2 is also known as?

A

Riboflavin

20
Q

The structure of vitamin B2 (Riboflavin) is known for what two components?

A

Flavin Molecule + Ribitol

21
Q

What is the coenzyme forms of vitamin B2 (Riboflavin)?

22
Q

What are some prominent sources of vitamin B2 (Riboflavin)?

A

Milk
Dairy Products
Eggs
Meat
Legumes
Enriched Grains

23
Q

Vitamin B2 (Riboflavin) is sensitive to?

24
Q

Vitamin B2 (Riboflavin) is essential in the function of what energy system?

A

Electron Transport Chain

25
Vitamin B2 functions in the activation of?
B6 Folate
26
Vitamin B2 functions in the reduction of?
Glutathione
27
Vitamin B2 acts in the synthesis of?
Niacin
28
Vitamin B2 deficiency showcases symptoms of?
Cheilosis (cracking of lips) Angular Stomatitis (cracking corner of mouth) Glossitis (inflammation of tongue magenta tongue)
29
Vitamin B2 deficiency tends to occur in which populations?
Elderly Some Cancers Pregnancy Elevated Metabolisms
30
What is an assessment for Vitamin B2?
Red Cell Glutathione Reductase (FAD is important in reducing glutathione)
31
Vitamin B3 is also known as?
Niacin
32
The structure of vitamin B3 (Niacin) is known for what two components?
Nicotinic Acid & Nicotinamide
33
What are the coenzyme forms of vitamin B3 (Niacin)?
NAD NADH NADP NADPH
34
What are some prominent sources of vitamin B3 (Niacin)?
(MFP) Meat, Fish, Poultry Enriched Grains Legumes
35
Synthesis of Vitamin B3 (Niacin) occurs from?
Tryptophan
36
How many mg of tryptophan equate to 1 mg of niacin synthesized?
60 mg for every 1 mg
37
In order for niacin synthesis to occur from tryptophan, what two vitamins and mineral are required?
B2, B6, Fe
38
Vitamin B3 (Niacin) functions primarily for?
Energy Transformation (FADH or NADH)
39
What are some of the energy pathways were Vitamin B3 operates?
Electron Transport Chain Glycolysis Pyruvate Dehydrogenase Krebs Cycle B-Oxidation
40
Pellagra is associated with Vitamin ___ Deficiency?
Vitamin B3
41
Pellagra is also known as the "4D's" for it's progressive degeneration? What are the "4D's"?
Dermatitis Diarrhea Dementia Death
42
Medication such as Isoniazid (TB meds) reduces _______ synthesis?
Reduced Niacin Synthesis
43
Vitamin B3 Deficiency is associated with?
Low Intake (alcoholics) Elevated Metabolism Low Tryptophan Diet
44
Vitamin B3 Toxicity showcases symptoms of?
Release of Histamine (flushing) Liver Injury Competition with Urate for Excretion Itching Elevated Glucose