Vit. B12

Question 1

Denumire B12

Answer 1

factor extrinsec- cobalamina- factor antipernicios

Question 2

Alcatuire B12

Answer 2

inel CORINIC- 4 nuclee pirolice unite prin leg coordinative de atomii de N si Co- a 5 a valenta este nucl BENZIMIDAZOLIC- iar a 6 a valenta este R (OH-CN-CH3-adenozil)
oh val 6 => B12 industriala

Question 3

Rol Biochimic B12

Answer 3

se leaga de facyorul intrinsec sau antipernicios - complex - intestin - absorbit si cu transportori - cel. mucoase.- circuit sangvin - absorbtie- se detaseaza FI- B12CO3+ - B12CO2+ - ATP rezulta coenz B12 adica adenozil cobalamina si metil cobalamina
transf homocisteina in metionina si metilmalonil CoA in succinil CoA

Question 4

VN B12

Answer 4

1-2 micrograme

Question 5

CARENTA B12

Answer 5

hiperhomocisteinemie-af. cardiace- deficit neurologic- tromboze
ANEMIE PERNICIOASA- ANEMIE MEGALOBLASTICA SI DEF NEUROLOGICE

Question 6

ANEMIE MEGALOBLASTICA sau macrocitara

Answer 6

incapacitatea sint. de globule rosii normale in maduva (apar megaloblaste si reticulocite)

Question 7

care este deficitul neurologic al B12

Answer 7

iritabilitate- apatie- mers si vorbire incoerenta- scad raspunsurile reflexe- infarct miocardic dat hiperhomocisteinemiei