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CELL MICRO S1 > Viruses of skin > Flashcards

Viruses of skin Flashcards

1
Q

localised infection of skin is where?

A

basal cells and fibroblasts

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2
Q

skin inf becomes systemic when?

A

if it enters the bs

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3
Q

describe the pathogenesis of a skin inf from inside?

A
  • inf of conjuctivae/mucosa of URT
  • viral replication in regional lymph nodes
    PRIMARY VIRAEMIA
  • viral replication in liver, spleen etc
    SECONDARY VIRAEMIA
  • inf of skin, appearance of vesicular rash
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4
Q

give 3 examples of viruses that cuase localised inf in the skin

A

1) HPV- warts
2) Molluscum contagiosum-water warts
3) Herpes simplex virus- cold sores

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5
Q

Molluscum contagiosum is from which family?

describe the size of ts genome?

A

poxvirus (only poxvirus that specifically infects humans)

large DNA genome

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6
Q

where does replication of Molluscum contagiosum occur?

A

human epidermis

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7
Q

HPV is from what family?

how big is its genome?

A

Papillomaviridae

small DNA genome

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8
Q

where does HPV replicate?

A

ONLY in differentiated keratinocytes

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9
Q

how many HPV types are there?

A

> 130 cutaneous and mucosal

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10
Q

cutaneous HPV causes what?

A

skin and genital warts, verrucas

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11
Q

what does high risk mucosal HPV cause?

A

cervical cancer

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12
Q

Herpes is from what family?

describe the genome

A

alphaherpesvirus

large DNA genome

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13
Q

Herpes presents on skin mainly as?

A

cold sore or
herpes keratitis - infection of eye
herpes whitlow - infection on hands or wrists
herpes gladiatorum and scrum pox - skin lesions in wrestlers and rugby players
eczema herpeticum - children with eczema become infected with HSV

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14
Q

HSV1 infection comes from where?

A

outside and inside

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15
Q

what are the 2 ways that HSV is transmitted?

A

direct contact w/ infected blisters (cold sore)

contact w/ saliva( also cont infectious virus)

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16
Q

Varicella zoster virus (VZV) causes what?

A

secondary disease of the skin, chickenpox

17
Q

Varicella zoster virus (VZV)

is from what family?

A

alphaherpesvirus

18
Q

describe the latency of VZV?

A

latency establishes in sensory ganglia of PNS

- reactivation results in shingles POSTHERPETIC neuralgia

19
Q

areHSV and VZV part of our lifelong virome?

A

yes

20
Q

what family is smallpox from?

describe the genetic info of smallpox

A

Variola virus- orthopoxviruses

large DNA genome

21
Q

describe the pathogenesis of smallpox

A
  • inhalation or transmission by scabs
  • multiplication in URT
  • multiply in lymphatics and lymph nodes
  • hemorrhage of small vessels of dermis, leading to rash and pox SECONDARY VIRAEMIA
  • movement to spleen, liver, bone marrow
22
Q

what virus was used to vaccinate against smallpox?

A

Vaccinia

23
Q

hand foot and mouth disease is caused by what virus?

A

Cocksackie

24
Q

Cocksackie comes from what family? what kind of genome?

A

Picornavirus

RNA genome

25
Q

how is Cocksackie transmitted?

A

from nose and throat secretions
blisteer fluid
faeces

26
Q

which disease causes maculopapular rashes on the skin?

what do they infect via?

A

measles, Rubella (german measles), Parovirus B12 (slapped cheek disease)

infect via resp route and are transported systemically to skin where they infect DERMAL endothelial cells

27
Q

how is HPV and Molluscum (growth formers) transmitted

A

dead cells slough off skin

28
Q

how are viruses that cause rashes transmitted?

A

via resp route (aerosols, droplets)

29
Q

how are viruses that enter through insect bite transmitted?

A

via another insect feed

30
Q

how does HPV and molluscum evade immune system?

A

make new virus particles in upper layers where there are no immune cells
don’t make antigens in lower layers, so aren’t recognised as foreign

31
Q

how do HSV, VZV and smallpox gain access to epidermis?

A

from blood/neurons

CELL MICRO S1 (16 decks)

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