Viruses Flashcards
Papular- purpuric glove and socks syndrome
Parvovirus B19
Aka erythema infectiosum
Persistent infection with chronic anaemia in patients with immunodeficiency
Parvovirus B19
Roseola
Aka
Abrupt onset of
Associated with
Aetiology
Features
Exanthem subitum HHV 6 or HHV 7 Fever for 3-4 days Seizures Defervese then rash
Influenza subtyped based on…
Action of haemagglutinin
Action of neuraminidase
Surface glycoproteins
Haemaglutinin also virus binding to sialic acid residues on respiratory epithelium
Neuraminidase cleaves residue, allows release of progeny virions into respiratory tree
Influenza
Seasonal variations caused by antigenic drift or shift?
Define
Antigenic drift
Mutation to surface glycoprotein
Shift when organism infected by two influenza strains: genetic reassortment results in significant change in virus
- occurs only in Influenza A
Mechanism of action Oseltamivir
Neuraminidase inhibitors
Prevents release of virions from host cell
Active against influenza A, B, H1N1
Adamantanes
Mechanism of action
Active against which virus
Target M2 protein of Influenza A
Involved in ion channels of viral membrane essential for viral replication
Herpangina
Viral cause
Features
Differentiate from Ludwig angina
Posterior pharyngeal, buccal, palatal ulcers
Fever
HSV gingivitis anterior- lips tongue gingiva
CMV
Symptoms/signs in SCT recipient
Fever Pan cytopenia Colitis Retinitis Pneumonitis
Valganciclovir
Used for…
S/e
Prophylaxis CMV post SCT
Neutropenia
Main disadvantage of
FOscarnet
Cidofovir
Amphoteracin B
Renal toxicity
CMV Treatment SCT recipient
Ganciclovir
Second line foscarnet
Third cidofovir
(Nephrotixic)
Herpes simplex in SCTR
Symptoms
Treatment
Stomatitis
Pneumonitis
Aciclovir
EBV in SCTR
Symptoms
Treatment
Fever
PTLD
Reduce immunosuppressive meds
Chemotherapy
HHV6 in SCTR
Symptoms
Treatment
Disseminated rash
Encephalitis
Pneumonia
BM supression
Ganciclovir
