Viruses

Question 1

Naked viruses

Answer 1

direct penetration: norovirus, rotavirus

receptor mediated endocytosis: polio

Question 2

DNA in nucleus except

Answer 2

HBV: copied to DNA by RT then back to RNA

Question 3

RNA in cytoplasm except

Answer 3

orthomyxovirus: uses 5’ end of mRNA in nucleus for primer

retroviruses

Question 4

Segmented genomes

Answer 4

influenza and rotavirus

Question 5

DNA viruses

Answer 5

HHAPPPy

Question 6

enveloped DNA viruses

Answer 6

pox, herpes, hepadna

Question 7

naked DNA viruses

Answer 7

polyoma, papilloma, adeno; parvo (ss)

Question 8

RNA viruses ss except

Answer 8

reoviruses

Question 9

RNA viruses enveloped except

Answer 9

Reo-, picorna-, calici-

Question 10

Viruses use RT

Answer 10

HIV, HBV

inhibited by lamivudine

Question 11

Parvovirus B19

Answer 11

small DNA, uses proerythroblast polymerase
margination of chromatin
erythema infectiosum (5ths disease)
hydrops fetalis

Question 12

HPV

Answer 12

oncogenic

E6 and E7 inactivate TSGs (Rb and p53)

Question 13

EBV

Answer 13

African Burkitt’s lymphoma by chromosomal translocation

Question 14

HHV8

Answer 14

Kaposi sarcoma

Question 15

HBV

Answer 15

hepatocellular carcinoma

Question 16

syncytium

Answer 16

fusion of cells –> multinucleated giant cell

RSV, herpes, retro-

Question 17

chromatin margination

Answer 17

HSV, adenovirus, parvovirus

Question 18

Koilocytosis

Answer 18

cytoplasmic vacuolization, pernuclear halo

HPV

Question 19

negri bodies

Answer 19

eosinophilic pyramidal cell cytoplasmic inclusion

rabies

Question 20

Owl’s eye

Answer 20

basophilic nuclear inclusion

CMV

Question 21

Cowdry type A

Answer 21

eosinophilic nuclear w/chromatin margination

HSV, VSV

Question 22

Cowdry type B

Answer 22

eosinophilic nuclear inclusion no chromatin margination

polio-adeno-