Autacoids

Question 1

Ethanolamine

Answer 1

1st generation antihistamine
Diphenhydramine
strong sedative, strong anti-cholinergic, anti-motion sickness, PD use

Question 2

Ethylaminediamines

Answer 2

1st generation antihistamine
Pyrilamine
mild anti-cholinergic, moderate sedative, GI side effects

Question 3

Alkylamines

Answer 3

1st generation antihistamine
Bromopheniramine, chloropheniramine
mild anti-cholinergic, mild sedative, OTC cold preparations

Question 4

Phenothiazines

Answer 4

1st generation antihistamine
Promethazine
strong sedative, strong anti-cholinergic, anti-emetic

Question 5

Cryproheptadine

Answer 5

1st generation antihistamine

moderate sedative, mild anti-cholinergic, anti-serotonergic

Question 6

2nd generation antihistamine

Answer 6

loratadine, cetirizine, fexofenadine
less lipid soluble, longer acting, less sedation
used for allergy

Question 7

Buspirone

Answer 7

5-HT1A agonist

anxiolytic

Question 8

Sumatriptan

Answer 8

5-HT1B/1D agonist

migraine (constricts vessels and inhibits nt release)

Question 9

Cryproheptadine

Answer 9

5-HT2A and H1 antagonist

uses: carcinoid syndrome, cold induced urticaria, for 5-HT syndrome

Question 10

Clozapine

Answer 10

5-HT7 antagonist and blocks dopamine
atypical antipsychotic with few extrapyramidal side effects
used for schizophrenia

Question 11

Ketanserin

Answer 11

5-HT2A antagonist and blocks alpha adrenergic receptors

blocks VSM contraction, platelet aggregation

Question 12

Ritanserin

Answer 12

5-HT2A antagonist

blocks VSM contraction, platelet aggregation

Question 13

Odansetron and Granisetron

Answer 13

5-HT3 antagonist

prevents nausea and vomiting after surgery and chemotherapy